perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-2-87-93perinatology-862Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESО влиянии селена на иммунный статус в комплексной терапии у детей с аутоиммунным тиреоидитомThe effect of selenium on the immune status in the complex treatment of children with autoimmune thyroiditisГабуловГ. Г.GabulovG. G.

Габулов Гусейн Гасан – проф. кафедры детских болезней 2-го Азербайджанского медицинского университета.

1007 Баку, ул. Анвара Гасымзаде, д. 14.

aaa@day.azДжабраиловаГ. И.JabrailovaG. I.

Джабраилова Гюнай Исрафил – ст. лаборант кафедры детских болезней 2-го Азербайджанского медицинского университета.

1007 Баку, ул. Анвара Гасымзаде, д. 14.

Азербайджанский медицинский университетАзербайджанAzerbaidzhan Medical UniversityAzerbaijan2019150520196428793Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/862

Изучено влияние селена на динамику ряда показателей иммунной системы в комплексной терапии у детей с аутоиммунным тиреоидитом. Обследован 31 ребенок (средний возраст 11,16±0,59 года). В 1-ю группу вошли 17 детей, которым, наряду с базисным лечением, назначали препарат селена по 100 мкг в сутки в течение 6 мес. Дети 2-й группы (n=14) принимали L-тироксин. В контрольную группу включили 15 практически здоровых детей такого же возраста. Средний уровень селена у детей из 1-й и 2-й групп в начале наблюдения составлял 69,23±1,52 мкг/л, в контрольной группе – 114,8±3,18 мкг/л. До лечения у детей 1-й и 2-й групп была выявлена Т-клеточная супрессия, средний уровень всех цитокинов (особенно TNF-α и IL-6) заметно превышал показатели у практически здоровых детей. Исследование показало, что с повышением уровня селена в сыворотке крови существенно снижался уровень антител к ткани щитовидной железы (р=0,001). К концу наблюдения в крови детей 1-й группы значительно повысилось содержание IgA (p=0,012) и IgG (p=0,044), отмечено увеличение количества лимфоцитов CD3+ (p=0,008), CD4+ (p=0,015), CD16+/56+ (p=0,010). У детей, принимавших селен в дополнение к основному лечению, снижение уровней TNF-α (p=0,028), IL-6 (p=0,002) и IL-1β (p=0,009) оказалось статистически значимым. Таким образом, результаты исследования свидетельствуют, что селен в комплексной терапии аутоиммунного тиреоидита значительно снижает титр антитиреоидных антител и положительно влияет на ряд важных показателей иммунного гомеостаза у детей.

The authors studied the effect of selenium on the dynamics of immune system indicators in children with autoimmune thyroiditis. They examined 31 children (average age of 11.16 ± 0.59 years). Group I included 17 children who took selenium (100 μg per day for 6 months) along with the basic treatment. Group II (n=14) took L-thyroxin. The control group included 15 healthy children of the same age. The average level of selenium in children of Group I and II was 69.23 ± 1.52 μg / l at the beginning of the study, in the control group it was 114.8 ± 3.18 μg / l. Before treatment, children in Group I and II had T-cell suppression, the average level of all cytokines (especially TNF-α and IL-6) was significantly higher than in practically healthy children. The study demonstrated that the level of the thyroid tissue antibodies decreased significantly (p=0.001) with an increase in the level of selenium in the blood serum. By the end of the study the content of IgA (p=0.012) and IgG (p=0.044) in Group I, as well as the number of lymphocytes CD3 + (p=0.008), CD4 + (p=0.015), CD16 + / 56 + (p=0.010) significantly increased. The authors observed statistically significant decrease in the levels of TNF-α (p=0.028), IL-6 (p=0.002) and IL-1β (p=0.009) in children who took selenium in addition to the main treatment. Thus, the results of the study suggest that selenium in the complex therapy of autoimmune thyroiditis significantly reduces the titer of antithyroid antibodies and positively affects a number of important indicators of immune homeostasis in children.

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The authors declare that there are no conflicts of interest present.