perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-3-17-27perinatology-889Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSАнти-NMDAR аутоиммунный энцефалит у детей и вирус простого герпеса 1-го типаAnti-NMDAR autoimmune encephalitis in children and herpes simplex virus-1https://orcid.org/0000-0002-8789-4750СкрипченкоЕ. Ю.SkripchenkoE. Yu.

Скрипченко Елена Юрьевна – к.м.н., ст. науч. сотр. отдела нейроинфекций и органической патологии нервной системы 

доцент кафедры психоневрологии 

зав. детским психоневрологическим отделением 

wwave@yandex.ruhttps://orcid.org/0000-0003-2943-7460ЖелезниковаГ. Ф.ZheleznikovaG. F.

Железникова Галина Федоровна – ст. науч. сотр. отдела клинической лабораторной диагностики 

https://orcid.org/0000-0002-7218-9346СкрипченкоН. В.SkripchenkoN. V.

Скрипченко Наталья Викторовна – засл. деятель науки РФ, д.м.н., проф., зам. директора по научной работе 

зав. кафедрой инфекционных заболеваний у детей

 

АлексееваЛ. А.AlekseevaL. A.

Алексеева Лидия Аркадьевна – д.м.н., вед. науч. сотр., рук. отдела клинической лабораторной диагностики 

СуровцеваА. В.SurovtsevaA. V.

Суровцева Анна Владимировна – к.м.н., мл. науч. сотр. отдела нейроинфекций и органической патологии нервной системы 

ФГБУ «Детский научно-исследовательский центр инфекционных болезней» ФМБА России; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России; ФГБУН «Институт мозга человека им. Н.П. Бехтеревой» РАНРоссияChildren’s Scientific and Clinical Center of Infectious Diseases; Saint Petersburg State Pediatric Medical University; Behterova Institute of Human BrainRussian FederationФГБУ «Детский научно-исследовательский центр инфекционных болезней» ФМБА РоссииРоссияChildren’s Scientific and Clinical Center of Infectious DiseasesRussian FederationФГБУ «Детский научно-исследовательский центр инфекционных болезней» ФМБА России; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияChildren’s Scientific and Clinical Center of Infectious Diseases; Saint Petersburg State Pediatric Medical UniversityRussian Federation2019300620196431727Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/889

Обзор посвящен ранее неизвестному аутоиммунному заболеванию центральной нервной системы – аутоиммунному энцефалиту с антителами к NMDA-рецепторам, описанному в 2007 г. Анти-NMDAR-энцефалит развивается у взрослых и детей в связи с опухолевым процессом и без такового, проявляется характерным синдромом неврологических и психических нарушений. Отдельную группу представляет анти-NMDAR-энцефалит, развивающийся после разрешения энцефалита, вызванного вирусом простого герпеса 1-го типа. Описаны клинические проявления анти-NMDAR-энцефалита у детей, отмечена эффективность ранней иммунотерапии. В перспективе дальнейших исследований обсуждаются вопросы патогенеза заболевания, а также связи между инфекцией вируса простого герпеса и развитием анти-NMDAR-энцефалита.

The review focuses on autoimmune encephalitis with antibodies to NMDA receptors, previously unknown autoimmune disease of the central nervous system, described in 2007. Anti-NMDAR encephalitis develops in adults and children, due to the tumor process and without it, it is manifested by characteristic syndrome of neurological and mental disorders. The authors separate anti-NMDAR encephalitis, which develops after the resolution of encephalitis caused by the herpes simplex virus-1. They describe the clinical manifestations of anti-NMDAR encephalitis in children and the effectiveness of early immunotherapy. Perspectively they discuss the pathogenesis of the disease, as well as the connection of herpes simplex virus infection and the development of anti-NMDAR encephalitis.

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The authors declare that there are no conflicts of interest present.