perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-3-28-36perinatology-890Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSОстеосаркома – на пути к персонализированной терапии. Часть II: персонализированная терапия будущегоOsteosarcoma – on the way to personalized therapy. Part II: personalized therapy of the futurehttps://orcid.org/0000-0002-8398-7001РыковМ. Ю.RykovM. Yu.

Рыков Максим Юрьевич – к.м.н., зам директора

доцент кафедры онкологии лечебного факультета

гл. внештатный детский специалист-онколог Минздрава России по Центральному федеральному округу

SPIN-код: 7652-0122

wordex2006@rambler.ruhttps://orcid.org/0000-0003-2310-3259СенжаповаЭ. Р.SengapovaE. R.

Сенжапова Эльмира Рифатовна – к.м.н., науч. сотр. отделения опухолей опорно-двигательного аппарата

ФБГУ «Национальный медицинский исследовательский центр онкологии им. академика Н.Н. Блохина» Минздрава России, НИИ детской онкологии и гематологии; ФГАОУ ВО «Первый московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияBlockhin Medical Research Center of Oncology; Sechenov First Moscow State Medical University (Sechenov University)Russian FederationФБГУ «Национальный медицинский исследовательский центр онкологии им. академика Н.Н. Блохина» Минздрава России, НИИ детской онкологии и гематологииРоссияBlockhin Medical Research Center of OncologyRussian Federation2019300620196432836Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/890

Саркомы костей составляют 7% в структуре злокачественных новообразований у детей, из них 35–50% – остеосаркомы. Значительная часть пациентов выявляется на распространенных стадиях заболеваний, что диктует необходимость поиска новых подходов к лечению. При этом оптимальная терапевтическая стратегия неизвестна, результаты лечения детей остаются неудовлетворительными. В части II описаны достижения в области персонализированной терапии, которые иллюстрируют вектор развития принципов терапии столь сложных заболеваний, которые еще несколько лет назад являлись для большинства пациентов фатальными.

Bone sarcomas account for 7% in the structure of malignant tumors in children, osteosarcomas take 35–50% of them. A significant proportion of patients are diagnosed at the spread stages of the disease, dictating the need to search for new approachesto treatment. Herewith the optimal therapeutic strategy is unknown, the results of treatment of children remain unsatisfactory. Part II describes the achievements in the field of personalized therapy, illustrating the vector of development of the principles of treatment of such complex diseases, which were fatal for most patients a few years ago.

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The authors declare that there are no conflicts of interest present.