perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-3-37-50perinatology-891Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSПребиотические компоненты грудного молока и возможность повторения их эффектов в формулах детского питанияPrebiotic components of breast milk and the possibility of repeating their effects in infant formulasСкиданИ. Н.SkidanI. N.

Скидан Игорь Николаевич – к.м.н., рук. научного отдела компании 

med_adviser@bibicall.ruГуляевА. Е.GulyaevA. E.

Гуляев Александр Евгеньевич – д.м.н., проф., вед. науч. сотр. центра наук о жизни

вед. науч. сотр. кафедры патофизиологии и общей патологии 

БельмерС. В.BelmerS. V.

Бельмер Сергей Викторович – д.м.н., проф. кафедры госпитальной педиатрии №2

Компания «БИБИКОЛЬ РУС»РоссияBIBIKOL RUSRussian FederationЦентр наук о жизни «Назарбаев Университет»; Медицинский институт, Сургутский государственный университетКазахстанCenter for Life Sciences “Nazarbayev University; Medical Institute, Surgut State UniversityKazakhstanФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияPirogov Russian Nartional Research Medical UniversityRussian Federation2019300620196433749Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/891

Аксиоматично, что грудное молоко является лучшей пищей для новорожденного, снабжающей его энергией, высококачественными пищевыми нутриентами, а также большим разнообразием биологически активных компонентов, необходимых для адекватного физического и психомоторного развития. Действуя либо в составе сложных биологических структур, либо отдельно, компоненты грудного молока, в том числе персонализированные микробные и иммунные, на молекулярном и клеточном уровне регулируют морфогенез, определяют характер метаболизма, направляют развитие мукозального иммунитета в организме ребенка. Понятно, что однозначно выявить какой-либо компонент грудного молока в качестве основного, определяющего его функциональную активность и обеспечивающего преимущества естественного вскармливания, невозможно. Цель данного обзора – описание роли пребиотиков в грудном молоке и формулах детского питания для формирования и поддержания здоровой микробиоты кишечника ребенка, представляющей ключевое звено формирования нормального пищеварения, функционально состоятельной иммунной системы и обмена веществ.

It is fundamental truth that breast milk is the best food for a newborn, providing it with energy, high-quality nutrients, as well as a large variety of biologically active components necessary for adequate physical and psychomotor development. Acting either as part of complex biological structures or separately, the breast milk components, including personalized microbial and immune, regulate morphogenesis at the molecular and cellular level, determine the metabolism nature, guide the development of mucosal immunity in the child’s body. It is impossible to identify any component of breast milk as the main component that determines its functional activity and provides the benefits of natural feeding. The purpose of this review is to describe the role of prebiotics in breast milk and infant formula for the formation and maintenance of a healthy baby intestinal microbiota, which is a key element in the formation of normal digestion, a functionally sound immune system and metabolism.

грудное вскармливаниедетские адаптированные смесиолигосахариды грудного молокаинулинолигофруктозаOrafti®Synergy1breastfeedingadapted infant formula adaptedoligosaccharides of breast milkinulinoligofructoseOrafti®Synergy1И.Н. Скидан является руководителем научного отдела компании «БИБИКОЛЬ РУС», эксклюзивного дистрибьютора детских адаптированных смесей на основе цельного козьего молока в Российской Федерации; А.Е. Гуляев и С.В. Бельмер подтверждают отсутствие конфликта интересов и финансовой поддержки, о которых необходимо сообщить.I.N. Skidan is the head of the scientific department of Bibicall-RUS Company, the exclusive distributor of infant adapted formulae based on whole goat milk in the Russian Federation; A.E. Gulyaev and S.V. Belmer confirm the absence of conflict of interests and financial support, which must be reported.ReferencesVictora C.G., Bahl R., Barros A.J., França G.V., Horton S., Krasevec J. et al. 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The authors declare that there are no conflicts of interest present.