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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">perinatology-90</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Влияние антенатальной йодной профилактики на рост и развитие детей первого года жизни</article-title><trans-title-group xml:lang="en"><trans-title>Impact of antenatal iodine prophylaxis on the growth and development of infants during the first year of life</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сандакова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sandakova</surname><given-names>E. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капустина</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapustina</surname><given-names>E. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трефилов</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trefilov</surname><given-names>R. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Софронова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sofronova</surname><given-names>L. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пермская государственная медицинская академия им. акад. Е.А. Вагнера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Acad. E.A. Vagner Perm State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>10</day><month>03</month><year>2016</year></pub-date><volume>60</volume><issue>1</issue><fpage>71</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/90">https://www.ped-perinatology.ru/jour/article/view/90</self-uri><abstract><p>Представлены результаты сравнения физического развития, заболеваемости и показателей ультразвукового исследования щитовидной железы детей первого года жизни в зависимости от качества антенатальной йодной профилактики. 1-ю группу составили 20 мальчиков и 23 девочки с оптимальной антенатальной йодной профилактикой (использование Йодомарина®, начало профилактики до 12-й недели беременности, доза йода более 200 мкг в сутки, регулярный прием), 2-ю группу — 26 мальчиков и 23 девочки с дефектами антенатальной йодной профилактики. В 1-й группе оптимальной йодной профилактики при рождении у девочек значительно реже встречалась внутриутробная гипотрофия. К году жизни дети 1 -й группы, преимущественно мальчики, были более рослыми в сравнении с детьми 2-й группы. Детям с дефектами антенатальной йодной профилактики по данным анализа первичной медицинской документации чаще диагностировали перинатальное поражение ЦНС (37,5% против 61,4%). Ультразвуковое исследование щитовидной железы, проведенное в возрасте 1 года у 18 и 19 детей 1-й и 2-й групп соответственно показало отсутствие значимых различий объема железы, однако неоднородная структура органа встречалась только у детей 2-й группы (26,3%). Частота перинатального поражения ЦНС и выявления неоднородной структуры щитовидной железы напрямую зависела от сроков начала йодной профилактики.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents the results of comparing the physical development, morbidity, and thyroid ultrasound findings of infants during the first year of life in relation to the quality of antenatal iodine prophylaxis. Group 1 consisted of 20 boys and 23 girls who had undergone optimal antenatal iodine prophylaxis with Iodomarin® initiated at less than 12 weeks' gestation and regularly used in a dose of above 200 ug/day; Group 2 included 26 boys and 23 girls with inadequate antenatal iodine prevention. In Group 1, intrauterine hypotropy was much less common in the girls at birth. By one year of fife, predominantly the boys in this group were taller than the infants in Group 2. Analysis of primary medical records indicated that Group 2 babies were more frequently diagnosed with perinatal central nervous system (CNS) lesion than Group 1 ones (61,4% vs. 37,5%). Thyroid ultrasound study performed at the age of 1 year in 18 and 19 infants from Groups 1 and 2, respectively, indicated no significant differences in the volume of the organ; however, its heterogeneous structure was found only in Group 2 (26,3%). The rate of perinatal CNS lesion and that of detection of the heterogeneous structure of the thyroid were directly dependent on the time to initiate iodine prophylaxis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>беременные женщины</kwd><kwd>йодный дефицит</kwd><kwd>антенатальная йодная профилактика</kwd><kwd>Йодомарин®</kwd><kwd>щитовидная железа</kwd><kwd>физическое развитие.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infants</kwd><kwd>pregnant women</kwd><kwd>iodine deficiency</kwd><kwd>antenatal iodine prophylaxis</kwd><kwd>Iodomarin'1'</kwd><kwd>thyroid</kwd><kwd>physical development.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Щеплягина Л.А., Долбова СИ. Эффективность профилактики и коррекции дефицита йода у детей раннего возраста. Педиатрия 2006; 4: 75—80. (ShhepljaginaLA., Dolbova S.I. 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