perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-4-19-25perinatology-923Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSПреэклампсия матери и программирование сердечно-сосудистого здоровья ребенкаPre-eclampsia in a mother and programming of the child’s cardiovascular healthhttps://orcid.org/0000-0002-4462-4179КовтунО. П.KovtunO. P.

д.м.н., проф., чл.- корр. РАН, ректор,

Екатеринбург

Yekaterinburg

https://orcid.org/0000-0002-8186-6329ЦывьянП. Б.TsyvianP. B.

д.м.н., проф., зав. кафедрой нормальной физиологии;

вед. науч. сотр.,

620028 Екатеринбург, ул. Репина, д. 3

Yekaterinburg

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава РоссииРоссияUral State Medical UniversityRussian FederationФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России; ФГБУ «Уральский научно-исследовательский институт охраны материнства и младенчества» Минздрава РоссииРоссияUral State Medical University; Mother and Child Care Research InstituteRussian Federation2019120920196441925Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/923

Представлен обзор литературы, посвященной проблеме программирования формирования структуры и функции сердечнососудистой системы у детей от матерей с преэклампсией. Такие дети имеют высокий риск развития сердечно-сосудистых заболеваний в последующей жизни. Показано, что в основе развития преэклампсии лежат дисфункция эндотелия, нарушения регуляции иммунных и воспалительных факторов при беременности. Экспериментальные исследования идентифицируют эти факторы как ключевые эпигенетические факторы программирования состояния сердечно-сосудистой системы потомства. Современная концепция внутриутробного программирования, описывающая этот феномен, сфокусирована на трех основных областях исследований: экспериментальных моделях, имитирующих внутриутробную среду при  преэклампсии; изучении того, как у человека формируется патологический фенотип под влиянием указанных факторов; эпигенетических исследованиях воздействия преэклампсии на функцию сердечно-сосудистой системы. Обсуждаются перспективы профилактики эпигенетического программирования.

The authors present a review of the literature devoted to the problem of programming the formation of the cardiovascular system structure and function in children born from mothers with preeclampsia. These children are at high risk of developing cardiovascular diseases. Pre-eclampsia is caused by the endothelium dysfunction, deregulation of the immune and inflammatory factors during pregnancy. Experimental studies identify these factors as key epigenetic factors programming the condition of the cardiovascular system of the offspring. The modern concept of intrauterine programming, describing this phenomenon, focuses on three main areas of research: experimental models simulating the intrauterine environment with preeclampsia; research of the pathological phenotype formation under the influence of these factors; epigenetic studies of the influence of preeclampsia on the cardiovascular system functioning. The article discusses the perspectives of epigenetic programming prevention.

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The authors declare that there are no conflicts of interest present.