perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2019-64-5-14-20perinatology-964Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSНовые возможности профилактики и лечения острых респираторных вирусных инфекций у детей. Местные факторы защиты слизистой оболочки дыхательных путейNew methods of prevention and treatment of acute respiratory viral infections in children. Local protection factors of the respiratory mucosahttps://orcid.org/0000-0003-0547-3686ГеппеН. А.GeppeN. A.

д.м.н., проф., зав. кафедрой детских болезней Института здоровья детей,

119435 Москва, ул. Б. Пироговская, д. 19, стр. 1

Moscow

geppe@mail.ruhttps://orcid.org/0000-0001-6062-5334ОзерскаяИ. В.OserskayaI. V.

к.м.н., асс. кафедры детских болезней Института здоровья детей,

119435 Москва, ул. Б. Пироговская, д. 19, стр. 1

https://orcid.org/0000-0001-5071-9302КолосоваН. Г.KolosovaN. G.

к.м.н., доцент кафедры детских болезней Института здоровья детей,

119435 Москва, ул. Б. Пироговская, д. 19, стр. 1

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation2019131120196451420Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20192019Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/964

Острые респираторные вирусные инфекции (ОРВИ) занимают лидирующие позиции в структуре заболеваний у детей. Отделяемое из носа, заложенность носа и затруднение носового дыхания – типичные и самые беспокоящие симптомы ОРВИ. Местные защитные факторы слизистой оболочки респираторного тракта (эпителиальный барьер, мукоцилиарный клиренс, антимикробные пептиды, иммуноглобулин А, микробиота) препятствуют проникновению возбудителей респираторных инфекций. Поддержание физиологического состояния слизистой оболочки играет важную роль в предотвращении ОРВИ у детей. В основе лечения ОРВИ у детей лежат обеспечение ухода и поддерживающие мероприятия. Орошение полости носа солевыми растворами способствует удалению слизи, механическому очищению, стимулирует мукоцилиарный клиренс, уменьшает отек слизистой оболочки и снижает потребность в применении деконгестантов. Новое средство для орошения полости носа назальный спрей «Аквалор протект» содержит 45% морской воды со слабогипертонической концентрацией солей (1,5%) и экстракт бурых водорослей Ascophillum nodosum. Основные полисахариды бурых водорослей фукоидан и аскофиллан обладают широким спектром биологической активности, в том числе противовоспалительным и противовирусным свойствамим. Добавление экстракта бурых водорослей к солевому раствору может способствовать повышению эффективности ирригационной терапии при лечении и профилактике ОРВИ у детей.

Acute respiratory viral infections (ARVI) are the most common diseases among children. The typical and most disturbing symptoms of ARVI are nasal discharge, nasal congestion and difficulty in nasal breathing. Local protective factors of the respiratory mucosa (epithelial barrier, mucociliary clearance, antimicrobial peptides, immunoglobulin A, microbiota) prevent the penetration of respiratory infections. To prevent ARVI in children it is important to maintain the physiological state of the mucous membrane. ARVI treatment in children is based on care and supportive activities. By irrigating nasal cavity with saline one removes mucus, mechanical impurities, stimulates mucociliary clearance, reduces swelling of the mucous membrane and need for decongestants. The new nasal spray Aqualor Protect contains 45% of sea water with a slightly hypertonic concentration of salts (1.5%) and Ascophillum nodosum brown algae extract. The main polysaccharides of brown algae - fucoidan and ascofillan - have a wide range of biological actions, including anti-inflammatory and antiviral properties. The extract of brown algae added to saline helps to increase the effectiveness of irrigation therapy in the treatment and prevention of acute respiratory viral infections in children.

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The authors declare that there are no conflicts of interest present.