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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2019-64-5-183-188</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-989</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Менингиты у детей раннего возраста. Критерии ранней диагностики</article-title><trans-title-group xml:lang="en"><trans-title>Meningitis in children of early age. Criteria for early diagnostics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7763-5512</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиуллина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaliullina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., доц. кафедры детских инфекций,</p><p>420012 Казань, ул. Бутлерова, д. 49</p><p>420140 Казань, пр. Победы, д. 83</p></bio><bio xml:lang="en"><p>Kazan</p><p>Tatarstan</p></bio><email xlink:type="simple">svekhal@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1050-9081</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анохин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Anokhin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. кафедрой детских инфекций,</p><p>420012 Казань, ул. Бутлерова, д. 49</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9013-4402</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаертынов</surname><given-names>Х. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Khayertynov</surname><given-names>Kn. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доц. кафедры детских инфекций,</p><p>420012 Казань, ул. Бутлерова, д. 49</p><p>420140 Казань, пр. Победы, д. 83</p></bio><bio xml:lang="en"><p>Kazan</p><p>Tatarstan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагиева</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Sagieva</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка,</p><p>420012 Казань, ул. Бутлерова, д. 49</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6811-4966</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камашева</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamasheva</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доц. кафедры общей врачебной практики,</p><p>420012 Казань, ул. Бутлерова, д. 49</p><p>420140 Казань, пр. Победы, д. 83</p></bio><bio xml:lang="en"><p>Kazan</p><p>Tatarstan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алатырев</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Alatyrev</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. отделением анестезиологии и реанимации №2,</p><p>420140 Казань, пр. Победы, д. 83</p></bio><bio xml:lang="en"><p>Tatarstan</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России; ГАУЗ «Республиканская клиническая инфекционная больница им. профессора А.Ф. Агафонова» Минздрава Республики Татарстан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University; Agaphonov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГАУЗ «Республиканская клиническая инфекционная больница им. профессора А.Ф. Агафонова» Минздрава Республики Татарстан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Agaphonov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2019</year></pub-date><volume>64</volume><issue>5</issue><fpage>183</fpage><lpage>188</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/989">https://www.ped-perinatology.ru/jour/article/view/989</self-uri><abstract><p>Менингиты характеризуются преобладанием тяжелых форм и часто сопровождаются синдромами, угрожающими жизни.</p><sec><title>Цель исследования</title><p>Цель исследования. Определение наиболее информативных клинических проявлений менингитов у детей первых лет жизни для оптимизации ранней диагностики и лечения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В рамках ретроспективного аналитического исследования проанализировано 47 историй болезни детей, госпитализированных в Республиканскую клиническую инфекционную больницу Минздрава РТ (2014–2016 гг.). Диагноз устанавливали при наличии острого начала заболевания, характерной клинической симптоматики и по результатам люмбальной пункции. Лабораторная диагностика включала стандартный набор исследований.</p></sec><sec><title>Результаты</title><p>Результаты. Диагноз «менингит» был установлен 34 пациентам (72,3%), «менингоэнцефалит» – 13 (27,7%). Бактериальная при- рода менингита/менингоэнцефалита была выявлена в 30 (63,8%) случаях, вирусная – в 9 (19,1%; р&lt;0,01). Среди бактериальных возбудителей чаще всего причиной менингита был пневмококк (10 наблюдений), гемофильная палочка (8), Streptococcus agalactiae и менингококк – по 6. Высокую фебрильную лихорадку регистрировали у 38 (80,9%) обследованных, слабость, сонливость, изменение сознания разной степени выраженности – у 100%, рвоту – у 29 (61,7%), головную боль, «мозговой» крик – у 16 (34%), гиперестезию, симптом «материнских рук» – у 7 (15%), вынужденную позу – у 4 (8,5%), менингеальные знаки – у 34 (72,3%).</p></sec><sec><title>Заключение</title><p>Заключение. Наиболее диагностически значимыми симптомами ранней менингитов у детей служат высокая фебрильная лихорадка в сочетании с сонливостью и заторможенностью, рвотой без диареи.</p></sec></abstract><trans-abstract xml:lang="en"><p>Meningitis is characterized by the prevalence of severe forms and it is often accompanied by life-threatening syndromes.</p><sec><title>Purpose</title><p>Purpose. To determine the most informative clinical manifestations of meningitis in children in their first years of life to optimize early diagnosis and treatment.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The authors carried out a retrospective analytical study involving 47 cases of children hospitalized to the Republican Clinical Hospital for Infectious Diseases in 2014–2016. Their diagnose was based on the acute onset of the disease, characteristic clinical symptoms and the results of lumbar puncture. The laboratory diagnostics included a standard set of examinations.</p></sec><sec><title>Results</title><p>Results. Meningitis was diagnosed in 34 patients (72.3%), meningoencephalitis – in 13 patients (27.7%). 30 cases (63.8%) of meningitis / meningoencephalitis had a bacterial nature, and 9 cases (19.1%; p&lt;0.01) had a viral nature. The most common bacterial pathogens of meningitis was Pneumococcus (10 cases), hemophilus bacillus (8). Str. agalactiae (6) and meningococcus (6). 38 (80.9%) patients had high febrile fever, 1005 of patients had weakness, drowsiness, changes in consciousness of varying severity, 29 patients (61.7%) had vomiting, 16 patients ( 34%) – headache, “brain” cry, 7 patients (15%) – hyperesthesia, a symptom of “mother’s hands”, 4 patients (8.5%) – forced posture, 34 patients (72.3%) had meningeal signs.</p></sec><sec><title>Conclusion</title><p>Conclusion. The most significant symptoms of early diagnosis of meningitis in children are high febrile fever combined with drowsiness and retardation, vomiting without diarrhea.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>менингиты</kwd><kwd>клиническая картина</kwd><kwd>этиология</kwd><kwd>ранняя диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>meningitis</kwd><kwd>clinical picture</kwd><kwd>early diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Государственные доклады «О состоянии санитарно-эпидемиологического благополучия населения в Москве в 2015, 2016, 2017, 2018 годах». http://www.rospotrebnadzor.ru/documents [State reports «On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2015, 2016, 2017, 2018» (in Russ.)]</mixed-citation><mixed-citation xml:lang="en">Государственные доклады «О состоянии санитарно-эпидемиологического благополучия населения в Москве в 2015, 2016, 2017, 2018 годах». http://www.rospotrebnadzor.ru/documents [State reports «On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2015, 2016, 2017, 2018» (in Russ.)]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Najaf-Zadeh A., Dubos F., Hue V., Pruvost I., Bennour A., Martinot A. 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