Humoral markers of endothelial dysfunction in children of the first year of life born with intrauterine growth retardation syndrome

Abstract

The article presents data on the functional state of endothelium in children of the first year of life, born with different variants of intrauterine growth retardation syndrome. The main group consisted of 60 full-term newborns with hypotrophic and hypoplastic variants of intrauterine growth retardation syndrome. The comparison group included 20 full-term newborns with normal anthropometric indicators. The examination was conducted on 7–10 days of life and at the age of 1 year of life. Newborns of the main group had deviations in health status: perinatal damage to the central nervous system, anemia, irregular colonization of the intestinal microflora, hyperbilirubinemia. Violations of the functional state of the endothelium was manifested by a change in the ratio of vasoconstrictors and vasodilators, in particular, a reduced content of endothelin-1 and nitric oxide in the blood and an increased content of renin and vascular endothelial growth factor. During the first year of life, all children were diagnosed with physical underdevelopment. Violation of the functional state of the endothelium was manifested by an increase in the level of endothelin-1, which is a vasoconstrictor. The results obtained allow to suggest that the identified changes contribute to the disruption of blood circulation and gas exchange in the organs and systems that ensure the growth and development of children.