Molecular stress and chronic metabolic disorders
https://doi.org/10.21508/1027-4065-2020-65-5-12-22
Abstract
Stress is the response of the organism to various external and internal events. All response reactions change from metabolic processes to metabolic stresses in minutes or even seconds. The scientists most often discuss oxidative, nitrosative and carbonyl stresses which are characterized by the accumulation of free radicals and other reactive oxygen species, as well as active carbonyl compounds, in the cells and extracellular fluid. These active (signal) molecules are powerful nonspecific modifiers of the structure and function of proteins, lipids, carbohydrates, and they interfere with bioenergetics. Small doses of active signal molecules are necessary for adaptive reactions of the body, they inhibit metabolic disorders, especially protein disorders, but their excessive accumulation causes pathological processes with pronounced modification of proteins and cardiovascular, neurodegenerative, autoimmune, connective tissue diseases and cancer. The authors discuss possible protection and prevention measures of metabolic stress.
Keywords
Supporting agencies: Source of financing: The study was carried out within the framework of state Funding «Analysis of clinical and genetic polymorphism of disabled monogenic diseases in children to predict their course and identify molecular targets for optimizing treatment» АААА-А18-118051790107-2
About the Authors
E. A. Yurieva
Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
N. N. Novikova
Kurchatov Institute
Russian Federation
Russian Federation
Moscow
V. V. Dlin
Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
E. S. Vozdvizhenskaya
Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
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For citations:
Yurieva E.A., Novikova N.N., Dlin V.V., Vozdvizhenskaya E.S. Molecular stress and chronic metabolic disorders. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(5):12-22. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-5-12-22
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