Prognostic value of the pSOFA and PELOD 2 scales in assessing the risk of death in neonatal intensive care units
https://doi.org/10.21508/1027-4065-2020-65-5-37-41
Abstract
Objective. To assess the discriminatory ability of the PELOD 2 and pSOFA scales in the conditions of multidisciplinary neonatal intensive care unit.
Material and methods. It is a prospective, observational, single-center study. The end points are to assess the severity of the condition on the PELOD 2 and pSOFA scales; 28-day survival. The study includes 121 patients.
Results. While studying the discriminating power of the scales we have found that all scales have good model quality. At the same time, the pSOFA evaluation system has a statistically more significant (p<0.05) area under the ROC curve (0.903±0.09). Our analysis has not found significant differences in the characteristics of surrogate endpoints between the compared scales in the conditions of comparable points of separation of death risks (p<0.05).
Conclusion. The high discrimination ability of the pSOFA scale allows us to recommend it for clinical use in neonatal intensive care units.
About the Authors
G. A. Kudinava
Republican Children's Clinical Hospital
Russian Federation
Russian Federation
Ufa
P. I. Mironov
Bashkortostan State Medical University
Russian Federation
Russian Federation
Ufa
A. U. Lekmanov
Pirogov Research Institute of Clinical Surgery
Russian Federation
Russian Federation
Moscow
References
1. Pinto N.P., Rhinesmith E.W., Kim T.Y., Ladner P.H., Pollack M.M. Long-term function after pediatric critical illness: Results from the survivor outcomes study. Pe-diatr Crit Care Med 2017; 18: e122-e130 doi: 10.1097/PCC.0000000000001070.
2. Pollack M.M., Holubkov R, Funai T., Amy C., John B.T., Kathleen M. et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network: Pediatric intensive care outcomes: Development of new morbidities during pediatric critical care. Pediatr Crit Care Med 2014; 15: 821—827. DOI: 10.1097/PCC.0000000000000250
3. Pollack M.M., Holubkov R, Funai T., Amy C., John B.T., Kathleen M. et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network: Simultaneous prediction of new morbidity, mortality, and survival without new morbidity from pediatric intensive care: A new paradigm for outcomes assessment. Crit Care Med 2015; 43: 1699—1709. DOI: 10.1097/CCM.0000000000001081
4. Ferreira A.M., Sakr Y. Organ dysfunction: General approach, epidemiology, and organ failure scores. Semin Respir Crit Care Med 2011; 32: 543-551. DOI: 10.1055/s-0031-1287862
5. Leteurtre S, Duhamel A., Salleron J., Grandbastien B., Lacroix J., Leclerc F. Groupe Francophone de Reanimation et d’Urgences Pediatriques (GFRUP): PELOD-2: An update of the PEdiatric logistic organ dysfunction score. Crit Care Med 2013; 41: 1761-1773. DOI: 10.1097/CCM.0b013e-31828a2bbd
6. Matics T.J., Sanchez-Pinto L.N. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 2017; 171: e172352. DOI: 10.1001/jamapedi-atrics.2017.2352
7. Leteurtre S., Martinot A., Duhamel A., Gauvin F, Grandbastien B., Nam T.V. et al. Development of a pediatric multiple organ dysfunction score: Use of two strategies. Med Decis Making 1999; 19: 399-410. DOI: 10.1177/0272989X9901900408
8. Azoulay E., Vincent J.L., Angus D.C., Arabi Y.M., Brochard L., Brett S.J., Citerio G. et al. Recovery after critical illness: Putting the puzzle together-a consensus of 29. Crit Care 2017; 21: 296. DOI: 10.1186/s13054-017-1887-7
9. Schlapbach L.J., Straney L, Bellomo R., MacLaren G., Pilcher D. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med 2018; 44: 179-188. DOI: 10.1007/s00134-017-5021-8
10. Schlapbach L.J., Kissoon N. Defining pediatric sepsis. JAMA Pediatr 2018; 172: 312-314. DOI: 10.1001/jamapediat-rics.2017.5208
11. Kawasaki T., Shime N., Straney L., Bellomo R., MacLaren G., Pilcher D. et al. Paediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus. Intensive Care Med 2018; 44(6): 995-997. DOI: 10.1007/s00134-018-5188-7
12. Matics T.J., Pinto N.P., L. Sanchez-Pinto N. Association of Organ Dysfunction Scores and Functional Outcomes Following Pediatric Critical Illness Pediatr Crit Care Med 2019; 20(8): 722-727. DOI: 10.1097/PCC.0000000000001999
13. Leteurtre S., Martinot A., Duhamel A., Proulx F., Grandbastien B., Cotting J. et al. Validation of the paediatric logistic organ dysfunction (PELOD) score. Prospective, observation, multicenter study. Lancet 2003; 362: 192. DOI: 10.1016/S0140-6736(03)13908-6
14. TyppoK., Watson R.S., Bennett T.D., FarrisR.W.D. Outcomes of Day 1 Multiple Organ Dysfunction Syndrome in the PICU. Pediatr Crit Care Med 2019; 20: 914-922. DOI: 10.1097/PCC.0000000000002044
15. Khaertynov Kh.S., Anokhin V.A., Khaliullina S.V., Lubin S.A., Doncova N.V., Koroleva P.V. et al. Clinical and epidemiological features and organ dysfunction in newborns with neonatal sepsis. Rossiys-kiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2019; 64(5): 176-182. (in Russ). DOI: 10.21508/1027-4065-2019-64-5-176-182
16. Hsu H. E., Abanyie F., Agus M.S.D., Balamuth F., Brady P.W., Brilli R.G. et al. A National Approach to Pediatric Sepsis Surveillance. PEDIATRICS 2019; 144 (6): e20191790. DOI: 10.1542/peds.2019-1790
Review
For citations:
Kudinava G.A., Mironov P.I., Lekmanov A.U. Prognostic value of the pSOFA and PELOD 2 scales in assessing the risk of death in neonatal intensive care units. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(5):37-41. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-5-37-41
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