The role of polymorphism of antioxidative activity genes in the formation of disabling pathology of the central nervous system in preterm newborns
https://doi.org/10.21508/1027-4065-2020-65-5-42-46
Abstract
The study aims to establish the role of polymorphism of genes encoding antioxidant enzymes in the development of CNS pathology in extremely premature newborns. In 72 examined newborns we determined the total antioxidant ability and allelic polymorphism of the sod2 and GCLC genes. During the work carried out, we were able to identify that the existence of the C/T genotype of С60Т polymorphism of the sod 2 gene in extremely premature newborns is a risk factor for the development of ischemic CNS injury. The findings broaden the understanding of the role of the antioxidant mechanism in protecting the CNS of extremely premature newborns and are the subject of further studies.
About the Authors
O. A. Savchenko
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
E. B. Pavlinova
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
N. A. Polyanskaya
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
I. A. Kirshina
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
E. I. Kurmasheva
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
А. A. Gubich
Omsk State Medical University of Ministry of Healthcare of Russia
Russian Federation
Russian Federation
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Review
For citations:
Savchenko O.A., Pavlinova E.B., Polyanskaya N.A., Kirshina I.A., Kurmasheva E.I., Gubich А.A. The role of polymorphism of antioxidative activity genes in the formation of disabling pathology of the central nervous system in preterm newborns. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(5):42-46. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-5-42-46
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