Molecular and genetic aspects of essential arterial hypertension in children
https://doi.org/10.21508/1027-4065-2020-65-5-54-57
Abstract
The article presents the results of clinical, molecular genetic data on the role of polymorphism of renin-angiotensin system genes ADD1, AGT, AGTR1, AGTR2, CYP11B2, GNB3, NOS3 in children with essential hypertension, taking into account the results of 24-hour blood pressure monitoring. The main Group consisted of 16 children (13 boys and 3 girls) aged from 13 to 17 years with essential arterial hypertension. The results of the study indicate a significant contribution of genetic factors to the development and progression of arterial hypertension in children.
Keywords
children,
essential arterial hypertension,
gene polymorphism,
ADD1,
AGT,
AGTR1,
AGTR2,
CYP11B2,
GNB3,
NOS3
About the Authors
G. A. Ignatenko
Gorky Donetsk National Medical University
Russian Federation
Russian Federation
D. O. Lastkov
Gorky Donetsk National Medical University
Russian Federation
Russian Federation
A. V. Dubovaya
Gorky Donetsk National Medical University
Russian Federation
Russian Federation
Yu. V. Naumenko
Gorky Donetsk National Medical University; Gusak Institute of Urgent and Regenerative Surgery
Russian Federation
Russian Federation
References
1. National guidelines for the diagnosis, treatment and prevention of hypertension in children and adolescents. Recommendations of the IOC, the Russian medical society for arterial hypertension and the Association of pediatric cardiologists of Russia. Kardiovaskulyarnaya terapiya i profilakti-ka 2015; 8(4): 1—36. (in Russ.)
2. Rotar' О.Р. Prevalence of metabolic syndrome in different cities of the Russian Federation. Rossiyskiy kardiologicheskiy zhurnal 2012; 2: 55—62. (in Russ.)
3. Edleeva A.G., Khomich M.M., Volkov N.Yu., Leonova I.A., Yuryev V.V. Assessment of body composition as a way to identify predictors of metabolic syndrome in children. Profilakticheskaya i klinicheskaya medit-sina 2010; 3—4 (36—37): 183—186. (in Russ.)
4. Glotov A.S. Vashukova E.S., Kanaeva M.D., Dvoeglazova M.O., Danilova M.M., Pakin V.S. et а1 Study of Association of polymorphism of APOE, LPL and NOS3 genes with risk of vascular pathology in children and pregnant women. Ekologich-eskaya genetika 2011; 9(4): 25—34. (in Russ.)
5. Baudin B. Polymorphism in angiotensin II receptor genes and hypertension. Experimental Physiology 2005; 90(3): 277— 282. DOI: 10.1113/expphysiol.2004.0284566
6. Kuznetsova T.Yu. Gavrilov D.V., DudanovI.P. Effect of polymorphisms of the gene of endothelial NO-synthase and NA-DPH-oxidase on the development of complications of arterial hypertension. Kardiologiya 2008; 48(3): 27—33. (in Russ.)
7. Speicher M.R., Antonarakis S.E., Motulsky A.G. \fogel and Motulsky’s Human Genetics: Problems and Approaches (Re-post). Springer, 2010; 981—983. DOI: 10.1186/1479-7364-5-1-73
8. Williams J.S., Hopkins P.N., Jeunemaitre X., Brown N.J. CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. J Hypertens 2011; 29: 1913—1918. DOI: 10.1097/HJH.0b013e32834aa786
9. Porto P.I., Garcia S.I., Dieuzeide G. Renin-angiotensin-aldosterone system loci and multilocus interactions in young-onset essential hypertension. Clin Exp Hypertens 2015; 25(2): 117—130. DOI: 10.1081/ceh-120017932
10. Ignatenko G.A., Dzhodzhua R.A., Muhin I.V., Ignatenko T.S., Gavrilyak V.G. Clinical course of hypertensive syndrome in young patients with genetic polymorphism. Problemy ekologicheskoi i meditsinskoi genetiki i klinicheskoi immunologii 2019; 4(154): 60—66. (in Russ.)
11. Obrazcova G.I., Yur’ev V.V. Genetic aspects of the formation of arterial hypertension in children. Molekulyarnaya meditsina 2013; 3: 32—35. (in Russ.)
Review
For citations:
Ignatenko G.A., Lastkov D.O., Dubovaya A.V., Naumenko Yu.V. Molecular and genetic aspects of essential arterial hypertension in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(5):54-57. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-5-54-57
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