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New coronavirus infection (COVID-19) in children with acute lymphoblastic leukemia

https://doi.org/10.21508/1027-4065-2020-65-5-198-203

Abstract

Currently, the researchers from various countries have demonstrated that COVID-19 in children is diagnosed less frequently, and the course and severity of the pathological process is less pronounced than in adults. Children with COVID-19 often have asymptomatic and mild forms. However, the risk of developing severe course of COVID-19 is typical for children from risk groups. Newborns and young children, congenital malformations and concomitant diseases, primarily accompanied by immunodeficiency states of various etiologies (oncological and autoimmune diseases, diabetes mellitus) are the risk factors for the development of severe forms of coronavirus infection. The article presents two clinical cases of COVID-19 in children with acute lymphoblastic leukemia. It is shown that children with concomitant oncohematological pathology often have both mild and severe forms of coronavirus infection.

About the Authors

D. I. Sadykova
Kazan State Medical University
Russian Federation


V. A. Anokhin
Kazan State Medical University
Russian Federation


A. I. Ziatdinov
Children's Republican Clinical Hospital
Russian Federation

Kazan



S. A. Senek
Children's Republican Clinical Hospital
Russian Federation

Kazan



T. P. Makarova
Kazan State Medical University
Russian Federation


N. V. Samoilova
Kazan State Medical University
Russian Federation


Ahmed Arafat
Kazan State Medical University
Russian Federation


Yu. S. Melnikova
Kazan State Medical University
Russian Federation


References

1. Namazova-Baranova L.S., Murashkin N.N., Ivanov R.A. Biological therapy in the era of COVID-19. Vprosy sovremennoi pediatrii 2020; 19(2): 116—122. (in Russ.)

2. Zaplatnikov A.L., Svincickaya V.I. COVID-19 and children. RMZH 2020; 28(6): 20-22. (in Russ.)

3. Namazova-Baranova L.S. Coronavirus infection (COVID-19) in children (as of April 2020). Pediatricheskaya farmakologiya 2020; 17 (2): 85-94. (in Russ.). DOI: 10.15690/pf.v17i2.2094

4. Guidelines. Features of the clinical manifestations and treatment of the disease caused by the new coronavirus infection (COVID-19) in children. Version 2 (03.07.2020). (in Russ.).

5. Balduzzi A., Brivio E., Rovelli A., Rizzari C., Gasperini S., Melzi M. et al. Lessons after the early management of the COVID-19 outbreak in a paediatric transplant and haema-to-oncology centre embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Bone Marrow Transplant 2020; 1-6. DOI: 10.1038/s41409-020-0895-4

6. Dong Y., Mo X., Hu Y., Qi X., Jiang F, Jiang Z., Tong S. Epidemiology of COVID-19 Among Children in China. Pediatrics 2020; 145(6): e20200702. DOI: 10.1542/peds.2020-0702

7. Lowensteyn Y.N., Phijfer E.W., Simons J.V.L., Schelte-ma N.M., Mazur N.I., Nair H. et al. Respiratory syncytial virus-related death in children with Down syndrome: the RSV GOLD study. Pediatr Infect Dis J 2020; 39(8): 665-670. DOI: 10.1097/INF.0000000000002666

8. Perez-Padilla R., Fernandez R., Garcia-Sancho C., Franco-Marina F., Aburto O., Lopez-Gatell H. et al. Pandemic (H1N1) 2009 virus and Down syndrome patients. Emerg Infect Dis 2010; 16(8): 1312-1314. DOI: 10.3201/eid1608.091931

9. Zhang C., Wu Z., Li J.W., Zhao H., Wang G.Q. The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents 2020; 29: 105954. DOI: 10.1016/j.ijantimicag.2020.105954

10. Chen Z, Xiong H., Li J.X., Li H., Tao F., Yang Y.T. et al. COVID-19 with post-chemotherapy agranulocytosis in childhood acute leukemia: a case report. Zhonghua Xue Ye Xue Za Zhi 2020; 41(4): 341-343. DOI: 10.3760/cma.j.issn.0253-2727.2020.0004

11. Feng K., Yun Y.X., Wang X.F., Yang G.D., Zheng Y.J., Lin C.M. et al. Analysis of CT features of 15 children with 2019 novel coronavirus infection. Zhong-hua Er Ke Za Zhi 2020; 58(4):275-278. DOI: 10.3760/cma.j.cn112140-20200210-00071

12. Park J.Y., Han M.S., Park K.U., Kim J.Y., Choi E.H. First Pediatric Case of Coronavirus Disease 2019 in Korea. J Korean Med Sci 2020; 35(11): e124. DOI: 10.3346/jkms.2020.35.e124

13. Alattar R., Ibrahim T.B.H., Shaar S.H., Abdalla S., Shukri K., Daghfal J.N et al. Tocilizumab for the treatment of severe coronavirus disease 2019. J Med Virol 2020; 10.1002/jmv.25964. DOI: 10.1002/jmv.25964

14. Capra R., De Rossi N., Mattioli F., Romanelli G., Scarpazza C., Sormani M. et al. Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia. Eur J Intern Med 2020; 76: 31-35. DOI: 10.1016/j.ejim.2020.05.009

15. Toniati P., Piva S., Cattalini M., Garrafa E., Regola F., Castel-li F. et al. Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy. Autoimmun Rev 2020; 19(7): 102568. DOI: 10.1016/j.autrev.2020.102568


Review

For citations:


Sadykova D.I., Anokhin V.A., Ziatdinov A.I., Senek S.A., Makarova T.P., Samoilova N.V., Arafat A., Melnikova Yu.S. New coronavirus infection (COVID-19) in children with acute lymphoblastic leukemia. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(5):198-203. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-5-198-203

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ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)