Experience in Course of Anti-IgE Therapy of Bronchial Asthma in Children
https://doi.org/10.21508/1027-4065-2020-65-6-116-121
Abstract
The results of the clinical approbation of Patient-specific therapy of bronchial asthma in children using the course method of application of the monoclonal antibodies (anti-IgE-therapy) by the Ministry of Health are summarized in order to assess the effect of this type of treatment on the disease exacerbation rate, including those associated with the seasonal acute respiratory infections. The conclusion was made regarding the high clinical efficiency in relation to all parameters studied and safety of this type of the treatment. It was determined that the monitoring of the level of specific IgE receptors on basophils using the cytoflowmetry method, which is concomitant to anti-IgE therapy, makes it possible to predict the efficiency and individual duration of anti-IgE therapy for uncontrolled atopic bronchial asthma in children.
Keywords
children,
bronchial asthma,
exacerbation rate,
respiratory infections,
omalizumab course treatment,
clinical efficiency,
IgE receptors on basophils,
cytoflowmetry
Supporting agencies: The work was performed within the framework of the clinical approbation of the Ministry of health of the Russian Federation No. 2018-46-12 «Personalized therapy of bronchial asthma in children using the course using monoclonal antibodies (anti-IgE therapy)».
About the Authors
S. E. Dyakova
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
Yu. L. Mizernitskiy
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
L. V. Sokolova
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
I. E. Zorina
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
A. E. Bogorad
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
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For citations:
Dyakova S.E., Mizernitskiy Yu.L., Sokolova L.V., Zorina I.E., Bogorad A.E. Experience in Course of Anti-IgE Therapy of Bronchial Asthma in Children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(6):116-121. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-6-116-121
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