Multiple subpleural cysts in the lungs in a child with Down’s syndrome
https://doi.org/10.21508/1027-4065-2021-66-4-95-100
Abstract
Down’ssyndrome is the most common chromosomal abnormality in live births. Due to the complete or partialtrisomy of chromosome 21the Down’s syndrome causes cognitive impairment, dysmorphic features and congenital mal formations. Pulmonary disease is the most common cause of death in patients with Down’s syndrome. The article highlights the pulmonological problems of the patients, and it also describes a clinical case of a child with Down’s syndrome with pulmonary pathology.
About the Authors
N. S. Lev
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
M. V. Kostyuchenko
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
I. E. Zorina
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
L. V. Sokolova
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
Yu. L. Mizernitsky
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
References
1. Karmiloff-Smith A., Al-Janabi T., D’Souza H. The importance of understanding individual differences in Down syndrome. F1000Res 2016; 5: F1000 Faculty Rev-389. DOI: 10.12688/f1000research.7506.1
2. Roizen N.J., Patterson D. Down’s syndrome. Lancet 2003; 361: 1281–1289. DOI: 10.1016/S0140-6736(03)12987-X
3. Reeves R.H., Baxter L.L., Richtsmeier J.T. Too much of a good thing: mechanisms of gene action in Down syndrome. Trends Genet 2001; 17(2): 83–88. DOI: 10.1016/S0168-9525(00)02172-7
4. Cheon M.S., ShimK.S., Kim S.H., Hara A., Lubec G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). Amino Acids 2003; 25(1): 41–47. DOI: 10.1007/S00726-003-0009-9
5. Colvin K.L., Yeager M.E. What people with Down Syndrome can teach us about cardiopulmonary disease. Eur Respir Rev 2017; 26(143): 160098. DOI: 10.1183/16000617.0098-2016
6. McDowell K.M., Craven D.I. Pulmonary complications of Down syndrome during childhood. J Pediatr 2011; 158(2): 319–325. DOI: 10.1016/j.jpeds.2010.07.023
7. Uppal H., Chandran S., Potluri R. Risk factors for mortality in Down syndrome. J Intellect Disabil Res 2015; 59: 873– 881. DOI: 10.1111/jir.12196
8. Watts R., Vyas H. An overview of respiratory problems in children with Down’s syndrome. Arch Dis Child 2013; 98: 812– 817. DOI: 10.1136/archdischild-2013-304611
9. LamD.J.,JensenC.C.,MuellerB.A. Pediatric sleep apnea and craniofacial anomalies: a population-based case–control study. Laryngoscope 2010; 120: 2098–2105. DOI: 10.1002/lary.21093
10. Pandit C., Fitzgerald D.A. Respiratory problems in children with Down syndrome. J Paediatr Child Health 2012; 48: E147–E152. DOI: 10.1111/J.1440-1754.2011.02077.X
11. Bertrand P., Navarro H., Caussade S. Airway anomalies in children with Down syndrome: endoscopic findings. Pediatr Pulmonol 2003; 36: 137–141. DOI: 10.1002/ppul.10332
12. MartinezE., Castaneda D., Jaramillo S. Altered immune parameters correlate with infection-related hospitalizations in children with Down syndrome. Hum Immunol 2016; 77(7): 594–599. DOI: 10.1016/j.humimm.2016.05.004
13. Piatti G., Allegra L., Ambrosetti U. Nasal ciliary function and ultrastructure in Down syndrome. Laryngoscope 2001; 111: 1227–1230. DOI: 10.1097/00005537-200107000-00016
14. Lev N.S., Mizernitskiy Yu.L. Clinical variants of interstitial lung disease in childhood. Moscow: ID «MEDPRAKTIKA-M», 2021; 368. ( in Russ.)
15. BushD., Abman S.H., Galambos C. Prominent intrapulmonary bronchopulmonary anastomoses and abnormal lung development in infants and children with Down syndrome. J Pediatr 2017; 180: 156–162.e1. DOI: 10.1016/j.jpeds.2016.08.063
16. Galambos C., Minic A.D., BushD. Increased lung expression of anti-angiogenic factors in down syndrome: potential role in abnormal lung vascular growth and the risk for pulmonary hypertension. PLoS One 2016; 11: e0159005. DOI: 10.1371/journal.pone.0159005
17. Saji T. Clinical characteristics of pulmonary arterial hypertension associated with Down syndrome. Pediatr Int 2014; 56: 297–303. DOI: 10.1111/ped.12349
18. Biko D.M., Schwartz M., Anupindi S.A. Subpleural lung cysts in Down syndrome: prevalence and association with coexisting diagnoses. Pediatr Radiol 2008; 38: 280–284. DOI: 10.1007/S00247-007-0699-3
19. Joshi V.V., KasznicaS., Khasma A., Amato S.S., Levine O.R. Cystic Lung dsease in Dawns syndrome: report of two cases. Pediatr Pathol 1986; 5: 79–86
20. Gonzalez O.R., Gomez I.G., Recalde A.L. Postnatal development of the cystic lung lesion of Down syndrome: suggestion that the cause is reduced formation of peripheral air spaces. Pediatr Pathol 1991; 11: 623–633. DOI: 10.3109/15513819109064794
21. Bruijn M., van der Aa L.B., van Rijn R.R. High incidence of acute lung injury in children with Down syndrome. Intensive Care Med 2007; 33: 2179–2182. DOI: 10.1007/s00134-007-0803-z
22. Biko D.M., Schwartz M., Anupindi S.A., Altes T.A. Subpleural lung cysts in Dawn syndrome: prevalence and association with coexisting diagnoses. Pediatr Radiol 2008; 38: 280–284. DOI: 10.1007/s00247-007-0699-3
23. Gyes-Ray K., Kirchener S., Stein S., Heller R., Htrnfnz-Schulman M. Cystic Lung disease in Dawn s syndrome. Pediatr Radiol 1999; 24: 137–138. DOI: 10.1007/bf02020173
24. Belyashova M.A., Ovsyannikov D.Yu., Koltunov I.E. Respiratory diseases in children with Down syndrome. Pediatriya. Zhurnal im. G.N. Speranskogo 2017; 96(2): 58–64 (in Russ.)] DOI: 10.17816/ped72164-169
25. Kostyuchenko M.V. Atlas of X-ray diagnostics of acute and chronic nonspecific lung diseases in children. Y.L. Mizernitskiy (ed.). Moscow: Medpraktika-M, 2014; 276. (in Russ.)
Review
For citations:
Lev N.S., Kostyuchenko M.V., Zorina I.E., Sokolova L.V., Mizernitsky Yu.L. Multiple subpleural cysts in the lungs in a child with Down’s syndrome. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(4):95-100. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-4-95-100
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