Complicated course of COVID-19 in a child with Bloch–Sulzberger syndrome
https://doi.org/10.21508/1027-4065-2021-66-6-103-107
Abstract
The authors describe a clinical case of a protracted course of a new coronavirus infection in a child with the development of severe complications against the background of a hereditary disease of neurocutaneous melanoblastosis, Bloch–Sulzberger syndrome. The progression and severity of the disease was caused by acute onset, lack of specific therapy at the onset of the disease and late seeking for medical help. For 2 months, the patient had long-term persistent SARS-CoV-2 viremia with the development of viral-bacterial pneumonia. A defect in the immune system in the early period of the disease contributed to the protracted course of the disease and the development of complications. The outcome of the disease in this patient was predetermined by the combination of etiological factors tropic to the respiratory system, the presence of background genetic pathology with the development of a pathological response of the innate and adaptive immune system of the body to massive replication of SARS-CoV-2 with the development of the late phase of COVID-19.
About the Authors
Yu. A. Ermolaeva
Siberian State Medical University
Russian Federation
Russian Federation
Moscow
Yu. G. Samoilova
Siberian State Medical University
Russian Federation
Russian Federation
Moscow
D. A. Kudlay
Sechenov First Moscow State Medical University (Sechenov University); State Research Center Institute of Immunology
Russian Federation
Russian Federation
Moscow
O. A. Oleynik
Siberian State Medical University
Russian Federation
Russian Federation
Moscow
References
1. Zaplatnikov A.L., Svintsitskaya V.I. Covid-19 and children. Russkii meditsinskii zhurnal 2020; 28(6): 20–22. (in Russ.)
2. Lu X., Zhang L., Du H., Zhang J., Li Y.Y., Qu J. et al. SARS-CoV-2 Infection in Children. N Engl J Med 2020; 382(17): 1663–1665. DOI: 10.1056/NEJMc2005073
3. Zhang B., Zhou X., Qiu Y., Song Y., Feng F., Feng J. et al. Clinical characteristics of 82 cases of death from COVID-19. PLoS One 2020; 15(7): e0235458. DOI: 10.1371/journal.pone.0235458
4. Bousquet J., Anto J.M., Iaccarino G., Czarlewski W., Haahtela T., Anto A. et al. Is diet partly responsible for differences in COVID-19 death rates between and within countries? Clin Transl Allergy 2020; 10: 16. DOI: 10.1186/s13601-020-00323-0
5. Melekhina E.V., Gorelov A.V., Muzyka A.D. Clinical characteristics of COVID-19 in children of different ages. s. Literature review as of April 2020. Voprosy prakticheskoi pediatrii 2020; 15(2): 7–20. (in Russ.) DOI: 10.20953/1817-7646-2020-2-7-20
6. Namazova-Baranova L.S. Coronaviral Infection (COVID-19) in Children (Situation on April 2020). Pediatricheskaya farmakologiya 2020; 17(2): 85–94. (in Russ.) DOI: 10.15690/pf.v17i2.2094
7. Malkova A., Kudlay D., Kudryavtsev I., Starshinova A., Yablonskiy P., Shoenfeld Y. Immunogenetic Predictors of Severe COVID-19. Vaccines (Basel) 2021; 9(3): 211. DOI: 10.3390/vaccines9030211
8. Гудима Г.О., Хаитов Р.М., Кудлай Д.А., Хаитов М.Р. Молекулярно-иммунологические аспекты диагностики, профилактики и лечения коронавирусной инфекции. Иммунология. 2021; 42 (3): 198–210. https://doi.org/10.33029/0206-4952-2021-42-3-198-210
9. Starshinova A., Malkova A., Yablonskiy P., Shoenfeld Y., Zinchenko U., Dovgalyk I., Kudlay D., Glushkova A. Efficacy of different types of therapy for COVID-19: a comprehensive review. Life. 2021; 11(8): 753.
10. Makhneva N.V., Tarasova Z.M., Narogan M.V., Davidenko E.B., Bobrov M.A., Khokhlova T.N. et al. Bloch–Sulzberger syndrome (a clinical and immunopathological observation). Klinicheskaya Dermatologiya i Venerologiya 2`013; 11(6): 36–45. (in Russ.)
11. Chernikova T.I., Shepilov L.A., Vasina T.N., Zubtsova T.I., Stavtseva S.N., Vislobokov A.V. Severe Bloch-Sulzberger syndrome in a newborn baby. Rossiyskiy Vestnik Perinatologii i Pediatrii 2014; 59(5): 59–62. (in Russ.)
12. Samoilova Y.G. Psychopathologic peculiarities of children, adolescents with obesity and metabolic syndrome Siberian Bulletin of Psychiatry and Narcology 2009. № 1 (52). С. 77-79.
Review
For citations:
Ermolaeva Yu.A., Samoilova Yu.G., Kudlay D.A., Oleynik O.A. Complicated course of COVID-19 in a child with Bloch–Sulzberger syndrome. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(6):103-107. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-6-103-107
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