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Особенности эндокринной регуляции пластических процессов у недоношенных детей и детей, малых для гестационного возраста
https://doi.org/10.21508/1027-4065-2023-68-5-11-16
Аннотация
Дети с низкой массой тела при рождении подвержены высокому риску возникновения ожирения и ассоциированных с ожирением заболеваний в будущем. В статье идентифицированы факторы риска и биомаркеры, обладающие наибольшей прогностической ценностью в отношении развития указанных метаболических заболеваний. Низкие концентрации инсулиноподобного фактора роста 1-го типа у детей c низкой массой тела при рождении ассоциированы с адипогенезом. Низкий уровень лептина может быть рассмотрен как биомаркер «догоняющего» роста. Эффекты внутриутробного воздействия лептина имеют долгосрочные последствия как детском, так и в подростковом возрасте. Уровень адипонектина положительно коррелирует с ожирением в раннем возрасте, но не в последующем. Быстрый темп постнатального роста ассоциирован с возникновением метаболического синдрома.
Заключение. Особенности эндокринной регуляции роста и динамики пластических процессов у недоношенных детей и детей, малых для гестационого возраста, сопряжены с избыточным накоплением жировой ткани, что может служить функциональным механизмом метаболического программирования отдаленных эндокринных и кардиометаболических нарушений.
Об авторах
М. Р. Шайдуллина
ГАУЗ «Детская Республиканская клиническая больница» Минздрава Республики Татарстан;
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Россия
Шайдуллина Мария Рустемовна — к.м.н., доц., зав. отделением эндокринологии Детской Республиканской клинической больницы, доц. кафедры эндокринологии
420138 Казань, ул. Оренбургский тракт, д. 140;
420012 Казань, ул. Бутлерова, д. 49
А. Т. Мансурова
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Россия
Мансурова Альфия Талгатовна — ординатор кафедры эндокринологии
420012 Казань, ул. Бутлерова, д. 49
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Рецензия
Для цитирования:
Шайдуллина М.Р., Мансурова А.Т. Особенности эндокринной регуляции пластических процессов у недоношенных детей и детей, малых для гестационного возраста. Российский вестник перинатологии и педиатрии. 2023;68(5):11-16. https://doi.org/10.21508/1027-4065-2023-68-5-11-16
For citation:
Shaydullina M.R., Mansurova A.T. Specific features of endocrine regulation of plastic processes in premature infants and children small for gestational age. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2023;68(5):11-16. (In Russ.) https://doi.org/10.21508/1027-4065-2023-68-5-11-16
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