Buy (150 RUB)
|Generate QR code
Open Access
Subscription or Fee Access
Evaluation of free and bound carnitine in young athletes
https://doi.org/10.21508/1027-4065-2023-68-5-61-64
Abstract
The study of the characteristics of carnitine metabolism in representatives of certain sports makes it possible to study the effect of physical loads of various nature on the body of a young athlete, and also makes it possible to assess the competitive potential and predict the tolerance of long-term and intense loads.
Purpose. This study is to investigate the characteristics of carnitine metabolism in young athletes of various specializations.
Material and methods. The study included athletes aged 14 to 18 who had been engaged in intense physical exercise for at least 12 hours per week forthe past 12 months or more. The control group consisted of healthy children aged 14 to 18 who were not involved in sports. In the blood serum of all study participants, the concentration of free carnitine, acetylcarnitine and acylcarnitines was determined. Based on the data obtained, ratios were calculated reflecting the activity of lipid beta-oxidation enzymes.
Results. We found that the content of free carnitine in the representatives of all the studied groups was within the normal range. At the same time, the level of free carnitine in the blood of athletes involved in field hockey was significantly lower than that of athletes-swimmers and representatives of the control group (p<0.001). It was also studied that, compared with athletes-swimmers and the control group, athletes-hockey players have significantly higher functional activity of carnitine palmitoyltransferase 1 (p<0.05) and lipid beta-oxidation enzymes (p<0.001).
Conclusion. In our work we have demonstrated that athletes involved in team sports (field hockey) have a more pronounced shift towards fatty acid oxidation compared to aerobic sports (swimming). A possible reason for the identified changes may be a more significant effect of alternating aerobic and anaerobic loads on lipid metabolism compared to exclusively aerobic activity.
About the Authors
N. V. Rylova
Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Moscow
A. S. Samoilov
Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Moscow
A. V. Zholinsky
Federal Scientific and Clinical Center for Sports Medicine and Rehabilitation of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Moscow
I. V. Bolshakov
Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Moscow
References
1. Gnoni A., Longo S., Gnoni G.V., Giudetti A.M. Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise? Molecules 2020; 25(1): 182. DOI: 10.3390/molecules25010182
2. Reuter S.E., Evans A.M. Carnitine and acylcarnitines: Pharmacokinetic, pharmacological and clinical aspects. Clin Pharmacokinet 2012; 51: 553–572. DOI: 10.1007/BF03261931
3. Tarasenko T.N., Cusmano-Ozog K., McGuire P.J. Tissue acylcarnitine status in a mouse model of mitochondrial beta-oxidation deficiency during metabolic decompensation due to influenza virus infection. Mol Genet Metab 2018; 125: 144–152. DOI: 10.1016/j.ymgme.2018.06.012
4. Sugiyama M., Hazama T., Nakano K., Urae K., Moriyama T., Ariyoshi T. et al. Effects of Reducing L-Carnitine Supplementation on Carnitine Kinetics and Cardiac Function in Hemodialysis Patients: A Multicenter, Single-Blind, Placebo-Controlled, Randomized Clinical Trial. Nutrients 2021;13(6): 1900. DOI: 10.3390/nu13061900
5. Dambrova M., Makrecka-Kuka M., Kuka J., Vilskersts R., Nordberg D., Attwood M.M. et al. Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. Pharmacol Rev 2022; 74(3): 506–551. DOI: 10.1124/pharmrev.121.000408
6. Yamada K., Bo R., Kobayashi H., Hasegawa Y., Ago M., Fukuda S. et al. A newborn case with carnitine palmitoyltransferase II deficiency initially judged as unaffected by acylcarnitine analysis soon after birth. Mol Genet Metab Rep 2017; 11: 59–61. DOI: 10.1016/j.ymgmr.2017.04.008
7. Paapstel K., Kals J., Eha J., Tootsi K., Ottas A., Piir A., Zilmer M. Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metabolic Endocrine 2016; 11: 13–18. DOI: 10.1016/j.ijcme.2016.05.001
8. Kumar Sarker S., Islam M.T., Sarower Bhuyan G., Sultana N., Begum M.N., Al Mahmud-Un-Nabi M. et al. Impaired acylcarnitine profile in transfusion-dependent beta-thalassemia major patients in Bangladesh. J Adv Res 2018; 12: 55–66. DOI: 10.1016/j.jare.2018.04.002
9. Achten J., Jeukendrup A. Optimizing fat oxidation through exercise and diet. Nutrition 2004; 20: 716–727. DOI: 10.1016/j.nut.2004.04.005
10. Purdom T., Kravitz L., Dokladny K., Mermier C. Understanding the factors that effect maximal fat oxidation. J Int Soc Sports Nutr. 2018; 15: 3. DOI: 10.1186/s12970–018–0207–1
11. Weiss A., Alack K., Klatt S., Zukunft S., Schermuly R., Frech T. et al. Sustained Endurance Training Leads to Metabolomic Adaptation. Metabolites 2022; 12(7): 658. DOI: 10.3390/metabo12070658
Review
For citations:
Rylova N.V., Samoilov A.S., Zholinsky A.V., Bolshakov I.V. Evaluation of free and bound carnitine in young athletes. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2023;68(5):61-64. (In Russ.) https://doi.org/10.21508/1027-4065-2023-68-5-61-64
Views:
216
Email this article 