

Adverse anthropogenic factors – a threat to the genetic and somatic health of children
https://doi.org/10.21508/1027-4065-2024-69-1-7-15
Abstract
The authors, based on a large number of studies (including their own) regarding the toxic effects of heavy and radioactive metals on children of different ages and with varying degrees of chronic exposure to such metals, present the risks of developing somatic and genetic diseases. The main mechanisms of the influence of the radiation factor on the child’s body and the causes of the formation of radiation-induced diseases are shown.
About the Authors
E. A. YurievaRussian Federation
Moscow
V. V. Dlin
Russian Federation
Moscow
M. V. Kushnareva
Russian Federation
Moscow
L. S. Baleva
Russian Federation
Moscow
A. E. Sipyagina
Russian Federation
Moscow
N. M. Karakhan
Russian Federation
Moscow
I. S. Dantsev
Russian Federation
Moscow
References
1. Kutsenko S.N. Fundamentals of toxicology. St. Petersburg, Foliant, 2004; 650. (in Russ.)
2. Fayzullina R.A., Maltsev S.V. Features of heavy metal metabolism in children with chronic gastroduodenitis. Kazanskii meditainskii zhurnal 2002; 83(2): 56–58. (in Russ.)
3. Baleva L.S., Sipyagina A.E. Predictors of the risk of formation of radiation-induced stochastic diseases in the generations of children from families of exposed parents is an urgent problem of our time. Ros vestn perinatol i pediatr 2019; 64(1): 7–14. (in Russ.)] DOI: 10.21508/1027–4065–2019–64–1–7–14
4. Kushnareva М.V., Yurieva E.A., Keshishyan E.S. Heavy Metals in the Women’s Breast Milk and the Health of Newborn Babies. Health Scie Res 2016; 3(3): 35–39.
5. Kushnareva M.V., Yurieva E.A., Keshishyan E.S. The content of heavy metals in the urine of healthy newborns and children with perinatal pathology. Ros vestn perinatol i pediatr 2015; 2: 37–41. (in Russ.)
6. Yuryeva E.A., Dlin V.V. Guidelines for the clinical and laboratory diagnosis of kidney diseases in children. Moscow: Overlay, 2020; 244. (in Russ.)
7. Vorsanova S.G., Demikova I.A., Ignatova M.S. Cytogenetic characteristics of children with nephropathies from a region contaminated with heavy metals. Nefrologiya i gemodializ 2000; 2(3): 166–170. (in Russ.)
8. Ignatova M.S., Kharina E.A., Degtyareva E.M., Fitin A.F., Trukhina O.V. First steps in pediatric econephrology. Ros vestn perinatol i pediatr 1994; 39(1): 31–33. (in Russ.)
9. Ignatova M.S., Osmanov I.M., Aksenova M.E., Dlin V.V. Ecologically caused kidney diseases in children and the use of seaweed preparations for their treatment. Ros vestn perinatol i pediatr 1996; 6:48–53. (in Russ.)
10. Akcenova M., Dlin V.V., Albegova M. Evolution of renal function in children with tubule-interstitial nephritis from cadmium and chromium-poisoned region. XXVI Congress of the European Renal Association, Sept. 5–8 1999; Madrid, Spain, p. 131.
11. Ignatova M.S., Dlin V.V., Klembovsky A.I. Nephropathy in a region contaminated with heavy metals. Ros vestn perinatol i pediatr 1997; 3: 45–49. (in Russ.)
12. Korovina N.A. Tubulointerstitial nephritis. Pediatric nephrology (a guide for physicians) Ed. M.S. Ignatova. Moscow: Meditsinskoe informatsionnoe agentstvo, 2011; 480–501. (in Russ.)
13. Pediatric Nephrology (guide for physicians). Ed. M.S. Ignatova. Moscow: Meditsinskoe informatsionnoe agentstvo, 2011; 683. (in Russ.)
14. Yuryeva E.A., Dlin V.V. Diagnostic handbook of a nephrologist (clinical and laboratory diagnostics). Moscow: Overlay, 2007; 355. (in Russ.)
15. Yuryeva E.A., Dlin V.V., Kushnareva M.V., Bochenkov S.V., Vozdvizhenskaya E.S. Bisphosphonates in the treatment of calcium metabolism disorders in children: over 40 years of use (lecture). Pediatriya. Vostochnaya Evropa 2023; 11(1): 130–140. (in Russ.)
16. Sorokin A.E. Clinical radiology. Textbook for high schools. Moscow: GЕOTAR-Media, 2008; 244. (in Russ.)
17. Mutovin T.R. Clinic, genetics, genomics and proteomics of hereditary pathology. Tutorial. Moscow: GEOTAR-Media, 2010; 882. (in Russ.)
18. Nomura T., Sipyagina A.E., Karakhan N.M. Cytogenetic effects and the possibility of their transgenerational transmission in the generations of people living in the regions of radionuclide contamination after the accident at the Chernobyl nuclear power plant. Ros vestn perinatol i pediatr 2016; 61(3): 95–97. (in Russ.)
19. Argunova V.S. Mutagenic factors and their influence on the human genetic apparatus. Tyumen: State Medical University of the Ministry of Health of the Russian Federation, 2018; 120. (in Russ.)
20. Sipyagina A.E., Baleva L.S., Suskov I.I., Pulatova M.K., Sharygin V.L., Malashina O.A. Hypersensitivity to low doses of radiation as the basis for the formation of chronic somatic diseases in children. Ros vestn perinatol i pediatr 2004; 49(5): 43–47. (in Russ.)
21. Yuryeva E.A., Dlin V.V., Kushnareva M.V., Vozdvizhenskaya E.S. Microelementoses in pathology in children. Pediatriya. Vostochnaya Evropa 2023; 11(2): 216–227. (in Russ.)
22. Burlakova E.B., Mikhailov V.F., Mazurik V.K. The system of redox homeostasis during radiation-induced genome instability. Rad Biology. Radioekologiya 2011; 41(5): 489–499. (in Russ.) URL: https://translated.turbopages.org/proxy_u/en-ru.ru.05510296-65e87bc9-3ce919f5-74722d776562/https/pubmed.ncbi.nlm.nih.gov/11721343/
23. Suskov I.I., Kuzmina N.S., Suskova V.S., Baleva L.S., Sipyagina A.E. The problem of induced genomic instability as the basis for increased morbidity in children exposed to low-intensity radiation in small doses. Rad. Biologiya. Radioekologiya 2006; 46(2): 167–177. (in Russ.) URL: https://translated.turbopages.org/proxy_u/en-ru.ru.95be094e-65e87c4c-6f5ea1bb-74722d776562/https/pubmed.ncbi.nlm.nih.gov/11721354/
24. Baleva L.S., Sukhorukov V.S., Sipyagina A.E., Karakhan N.M., Voronkova A.S., Sadykov A.R. The role of genomic instability and expression of the p53 protein gene network in oncogenesis in the I–II generations of children living in radiation-contaminated areas. Ros vestn perinatol i pediatr 2017; 62(1): 81–86. (in Russ.) DOI: 10.21508/1027–4065–2017–62–1–81–86
25. Sipyagina A.E., Baleva L.S., Karakhan N.M., Sukhorukov V.S. Role of Postradiation genome instability in evaluating the development of radiation-determined pathology in children after Chernobyl accident and investigation perspectives. AAS-CIT J Med 2015; 1(2): 18–22
26. Baleva L.S., Nomura T., Sipyagina A.E., Karakhan N.M., Yakusheva E.N., Egorova N.I. Cytogenetic effects and the possibility of their transgenerational transmission in the generations of individuals living in the regions of radionuclide contamination after the accident at the Chernobyl nuclear power plant. Ros vestn perinatol i pediatr 2016; 61(3): 87–95. (in Russ.) DOI: 10.21508/1027–4065–2016–61–3–87–94
27. Alexakhin R.M. The 61<sup>-st</sup> Session of the UN Scientific Committee on the Effects of Atomic Radiation. Rad Biologiya. Radioekologiya (Rad. Biology. Radioecology) 2014; 54(6): 657–658. (in Russ.) URL: https://elibrary.ru/item.asp?doi=10.7868/S0869803114060046
28. Nomura T., Baleva L.S., Ryo H., Adachi S., Sipyagina A.E., Karakhan N.M. Transgenerational effects of radiation on cancer and other disorders in mice and humans. J Radiat Cancer Res 2017; 8(3): 123–134. DOI: 10.4103/jrcr.jrcr_30_17
29. Cardozo R.S., Takahashi-Hyodo S., Peitl P.Jr., Ghilardi Ne-to T., Sakamoto-Hojo E.T. Evaluation of chromosomal aberrations, micronuclei and sister chromatid exchanges in hospital workers chronically exposed to ionizing radiation. Teratog Carcinog Mutagen 2001; 21: 431–439 DOI: 10.1002/tcm.1030
30. Unzhakov S.V., Lvova G.N., Chekova V.V., Semyachkina A.N., Baleva L.S., Zasukhina G.D., Kazantseva L.Z. DNA repair activity in children exposed to low doses of ionizing radiation as a result of the accident at the Chernobyl nuclear power plant. Geneticа 1995; 31: 1433–1437. (in Russ.)
31. Korsakov A.V., Troshin V.P., Mikhalev V.P., Zhilin A.V., Zhilina O.V., Vorobyeva D.A., Korotkova N.S. Comparative assessment of the frequency of cytogenetic disorders in the buccal epithelium of children in ecologically unfavorable territories of the Bryansk region. Toksikolog Vestn 2012; 1: 29–34. (in Russ.)
32. Sycheva L.P. Biological significance, criteria for de-termining and limits of variation of the full range of caryological parameters in assessing the cytogenetic status of a person. Meditsinskaya genetika 2007; 11(3): 11–15. (in Russ.) URL: https://elibrary.ru/hncuvx
33. Lin Y., Ma W., Benchimol S. А new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nature Genet 2000; 26(l): 122–127. DOI: 10.1038/79102
34. Baleva L.S., Sukhorukov V.S., Marshall T., Sipyagina A.E., Abe H., Voronkova A.S. et al. Higher risk for carcinogenesis for residents populating the isotopecontaminated territories as assessed by NanoString Gene Expression Profiling. J Translational Sci 2017; 3(3): 1–6. DOI: 10.15761/JTS.1000183
35. Wang L.B., Zheng S., Zhang S.Z., Peng J.P., Ye F., Fang S.C., Wu J.M. Expression of ST 13 in colorectal cancer and adjacent normal tissues. World J Gastroenterol 2005; 11(3): 336–339. DOI: 10.1186/1476–4598–11–29
36. Hedau S., Batra M., Singh U.R., Bharti A.C., Ray A., Das B.C. Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. J Cancer Res Ther 2015; 11(l): 158–164. DOI: 10.4103/0973–1482.140985
37. Vorobtsova I.E. Genetic consequences of ionizing radiation’s action for animals and men. Med Radiologiya 1993; 38(9): 31–34. (in Russ.)]
38. Yarilin A.A. The bases of immunology. Moscow: Meditsina, 1999; 608. (in Russ.)
39. Baleva L.S., Yakovleva I.N., Sipyagina A.E., Karakhan N.M., Karpeeva E.E., Buyankin V.M., Suskova V.S. Clinical and immunological disorders in children of different observation cohorts exposed to the radiation factor at various stages of ontogenesis. Rad Biologiya. Radioekologiya 2011; 51(1): 7–19. (in Russ.)] URL: https://naukarus.com/kliniko-immunologicheskie-narusheniya-u-detey-razlichnyh-kogort-nablyudeniya-podvergshihsya-deystviyu-radiatsionnogo-fakt
40. Baleva L.S., Sipyagina A.E., Yakovleva I.N., Karakhan N.M., Egorova N.I., Zemlyanskaya Z.K. Immunological features of disorders in children living in regions with different levels of radionuclide contamination after the accident at the Chernobyl nuclear power plant. Ros vestn perinatol i pediatr 2015; 60(3): 81–88. (in Russ.)
Review
For citations:
Yurieva E.A., Dlin V.V., Kushnareva M.V., Baleva L.S., Sipyagina A.E., Karakhan N.M., Dantsev I.S. Adverse anthropogenic factors – a threat to the genetic and somatic health of children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2024;69(1):7-15. (In Russ.) https://doi.org/10.21508/1027-4065-2024-69-1-7-15