Митохондриальная динамика и значение ее нарушений в развитии детских болезней. Часть I. Физиологические и неврологические аспекты

   Динамика митохондриальных преобразований в клетке вызывает в последние годы все больший интерес как представителей фундаментальной науки, так и исследователей в области прикладной медицины. Растет число наблюдений, доказывающих важное регуляторное влияние митохондриальной динамики на разнообразные физиологические и патологические процессы во многих, если не во всех, органных и тканевых структурах. Представляются все более важными перспективы изучения особенностей и регуляторов этих процессов для понимания патогенеза заболеваний, разработки их новых биомаркеров, а также технологий лечения.

   Цель настоящей статьи — обзор полученных в отношении митохондриальной динамики фактов, которые с точки зрения авторов заслуживают внимания педиатров.

   Объем соответствующей информации оказался слишком широк, чтобы уместиться в рамках одной статьи, что заставило разделить ее на несколько последовательных публикаций. В части I приведены сведения об основных процессах, включенных в понятие «митохондриальная динамика», о значении поддержания баланса последней для онтогенеза и тканевого гомеостаза, а также данные о ее нарушениях при болезнях нервной системы у детей.

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