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Neonatal thyrotoxicosis: clinical features, diagnosis and treatment
https://doi.org/10.21508/1027-4065-2025-70-3-106-114
Abstract
Neonatal thyrotoxicosis is a rare life-threatening disease characterized by the development of hyperthyroidism symptoms in newborns. In most cases, neonatal thyrotoxicosis occurs in children of mothers with recurrent diffuse toxic goiter and high titers of antithyroid antibodies in pregnant women. In rare cases, it is associated with genetic variants in the GNAS and TSHR genes. This article is devoted to the main issues of diagnosis and treatment of neonatal thyrotoxicosis, a comparative description of the forms of the disease depending on the etiologic factor is given. The final part of the article presents a clinical observation of transient neonatal thyrotoxicosis in a child born to a mother with recurrent diffuse toxic goiter. The experience of observing a patient with neonatal thyrotoxicosis reflects the importance of early diagnosis and timely initiation of antithyroid therapy in neonatal thyrotoxicosis.
About the Authors
D. O. Ivanov
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
L. V. Ditkovskaya
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
O. I. Maryina
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
M. M. Kostik
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
A. N. Malova
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
N. N. Saveliev
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
194100, St. Petersburg
References
1. Petryajkina E.E., Ovsyannikov D.Yu., Pushko L.V., Ry`bkina I.G., Korovina O.A., Teterkina A.O., et. al. Clinical observation of neonatal thyrotoxicosis. Pediatriya. 2019; 98 (2): 243–247. (in Russ.). DOI: 10.24110/0031-403X-2019-98-2-243-247
2. Vitti P., Hegedüs L. Thyroid Diseases: Pathogenesis, Diagnosis, and Treatment. New York: Springer, 2018. ISBN 978-3-319-45012-4. DOI: 10.1007/978-3-319-45013-1
3. Bolmasova A.V., Ryumina I.I., Pekareva N.A., Ionov O.V. Neonatal thyrotoxicosis in premature twins from mother with a history of diffuse toxic goiter. Neonatologiya: novosti, mneniya, obuchenie. 2018; 6 (3): 116–123 (in Russ.). DOI: 10.24411/2308-2402-2018-13006
4. Alexander E.K., Pearce E.N., Brent G.A., Brown R.S., Chen H., Dosiou C., et. al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017; 27 (3): 315–389. DOI: 10.1089/thy.2016.0457
5. Besanсon A., Beltrand J., Le Gac I., Luton D., Polak M. Management of neonates born to women with Graves’ disease: a cohort study. Eur J Endocrinol. 2014; 170 (6): 855–862. DOI: 10.1530/EJE-13-0994
6. Skorodok Yu.L., Ditkovskaya L.V. Lupus-like syndrome as a complication of thyreostatic therapy for diffuse toxic goiter. Pediatriya im. G.N. Speranskogo. 2005; 84 (6): 97–98 (in Russ.)
7. Fadeev V.V. Review of American Thyroid Association guidelines for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Klinicheskaja i jeksperimental’naja tireoidologija2018; 14 (3): 128–139 (in Russ.). DOI: 10.14341/ket9794
8. Banigе M., Polak M., Luton D. Research Group for Perinatal Dysthyroidism (RGPD) Study Group. Prediction of Neonatal Hyperthyroidism. J Pediatr. 2018; 197: 249–254.e1. DOI: 10.1016/j.jpeds.2018.01.071
9. Voroxobina N.V., Lovkova Yu.S., Kuzneczova A.V., Kovaleva Yu.V., Baranov V.L. Functional condition of the thyroid gland of newborns from methers with a diffuse toxic goiter. Medicinskij vestnik Yuga Rossii. 2019; 10 (3): 24–31 (in Russ.).DOI: 10.21886/2219-8075-2019-10-3-24-31
10. Bohîlțea R.E., Mihai B.M., Szini E., Șucaliuc I.A., Badiu C. Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis. Medicina (Kaunas). 2022; 59 (1): 36. DOI: 10.3390/medicina59010036
11. Samuels S.L., Namoc S.M., Bauer A.J. Neonatal Thyrotoxicosis. Clin Perinatol. 2018; 45 (1): 31–40. DOI: 10.1016/j.clp.2017.10.001
12. Stefan M., Faustino L.C. Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease. Front Endocrinol (Lausanne). 2017; 8: 57. DOI: 10.3389/fendo.2017.00057
13. Tong Y., Yue D., Xin Y., Zhang D. GNAS mutation is an unusual cause of primary adrenal insufficiency: a case report. BMC Pediatr. 2022; 22 (1): 472. DOI: 10.1186/s12887-022-03517-6
14. Rozhinskaya L.Ya., Sardaeva D.G., Kalinchenko N.Yu., Chukanova A.M., Tarbaeva N.V., Buryakina S.A., et. al. McCune–Albright syndrome: description of three clinical cases, features of diagnostics and treatment. Osteoporoz i osteopatii. 2021; 24 (3): 19–32 (in Russ.). DOI: 10.14341/osteo12932
15. Nicolaides N.C., Kontou M., Vasilakis I.A., Binou M., Lykopoulou E., Kanaka-Gantenbein C. McCune-Albright Syndrome: A Case Report and Review of Literature. Int J Mol Sci. 2023; 24 (10): 8464. DOI: 10.3390/ijms24108464
16. Lourenço R., Dias P., Gouveia R., Sousa A.B., Oliveira G. Neonatal McCune-Albright syndrome with systemic involvement: a case report. J Med Case Rep. 2015; 9: 189. DOI: 10.1186/s13256-015-0689-2
17. Ivanov D.O., Kozlova L.V., Derevczov V.V. Vegetative disfunction and adaptive reserve potential in children born with fetus growth delay in the first 6 months of life. Pediatr. 2016; 7 (4): 77–89 DOI: 10.17816/PED7477-89 (in Russ.). DOI: 10.218 86/2219-8075-2019-10-3-24-31
18. Paschke R., Niedziela M., Vaidya B., Persani L., Rapoport B., Leclere J. 2012 European thyroid association guidelines for the management of familial and persistent sporadic non-autoimmune hyperthyroidism caused by thyroid-stimulating hormone receptor germline mutations. Eur Thyroid J. 2012; 1 (3): 142–7. DOI: 10.1159/000342982
19. Watkins M.G., Dejkhamron P., Huo J., Vazquez D.M., Menon R.K. Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. Endocr Pract. 2008; 14 (4): 479–483. DOI: 10.4158/EP.14.4.479.
Review
For citations:
Ivanov D.O., Ditkovskaya L.V., Maryina O.I., Kostik M.M., Malova A.N., Saveliev N.N. Neonatal thyrotoxicosis: clinical features, diagnosis and treatment. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(3):106-114. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-3-106-114
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