Состояние здоровья и развитие детей, рожденных после экстракорпорального оплодотворения
Аннотация
Предмет обзора данных литературы: состояние здоровья и развитие детей, рожденных после экстракорпорального оплодотворения (ЭКО). Проведен анализ данных отечественных и зарубежных публикаций за период с 1995 до 2013 г. с преимущественным вниманием к крупномасштабным многоцентровым исследованиям. Результаты. Негативные перинатальные исходы (невынашивание, маловесность и их осложнения) обусловлены преимущественно «факторами со стороны родителей» — бесплодием, возрастом и сопутствующим комплексом метаболических, генетических и эпигенетических изменений, что отражается на качестве гамет и течении беременности, а также, вероятно, обусловливает повышенный (1,3—2) риск врожденных аномалий развития и потребность в их хирургической коррекции у детей после ЭКО в сравнении с детьми, родившимися в результате спонтанных беременностей. Единственный доказанный фактор субоптимальных перинатальных исходов, ассоциированный с методом ЭКО, — многоплодие. Данные о повышенной частоте соматической и другой патологии у детей после ЭКО противоречивы и не подтверждены крупными исследованиями; сравнение уровня генетических и эпигенетических нарушений затруднительно ввиду их редкой встречаемости. Открытым остается прогноз репродуктивного статуса и отсроченных заболеваний (онкологии, метаболических нарушений) у данной группы детей.
Об авторах
Е. С. Кешишян
Научно-исследовательский клинический институт педиатрии, Москва
Россия
Россия
д.м.н., проф., рук. отделения раннего возраста Центра коррекции развития детей раннего возраста НИКИ педиатрии
А. Д. Царегородцев
Научно-исследовательский клинический институт педиатрии, Москва
Россия
Россия
д.м.н., проф., советник ректора Российского национального медицинского университета им. Н.И. Пирогова 125412 Москва, ул. Талдомская, д.2
М. И. Зиборова
Научно-исследовательский клинический институт педиатрии, Москва
Россия
Россия
асп. Центра коррекции развития детей раннего возраста
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Рецензия
Для цитирования:
Кешишян Е.С., Царегородцев А.Д., Зиборова М.И. Состояние здоровья и развитие детей, рожденных после экстракорпорального оплодотворения. Российский вестник перинатологии и педиатрии. 2014;59(5):15-25.
For citation:
Keshishian E.S., Tsaregorodtsev A.D., Ziborova M.I. The health status of children born after in vitro fertilization. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(5):15-25. (In Russ.)
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