The state of erythrocyte membranes in newborn infants born to mothers with gestosis

Abstract

Objective: to study the specific structural and functional features of erythrocyte membranes in the neonatal infants (и=181) from mothers with gestosis in relation to the clinical course of an early postnatal adaptation process. A control group consisted of 42 neo-nates rom mothers with physiological pregnancy. The biophysical state of erythrocyte membranes was investigated by fluorescence spectroscopy at birth and on day 4 of life. The indicators of fluidity in the deep and paraprotein layers of phospholipids were determined in relation to the pyrene eximer-to-monomer fluorescence ratio. By day 4 of life, the neonatal infants of healthy mothers were found to have increased viscosity (decreased fluidity) of membranes, which may be considered as an adaptive compensation mechanism upon transition to new living conditions. In the neonates of mothers with gestosis, these membrane changes were less pronounced and those of mothers with severe gestosis had no significant increase in membrane viscosity by day 4 of life, which was associated with the more severe course of an early postnatal adaptation period.