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Diagnostic significance of inflammation and fibrogenesis mediators in chronic kidney disease in children
https://doi.org/10.21508/1027-4065-2026-71-1-64-73
Abstract
The search for highly sensitive biomarkers and predictors of early diagnostics of renal damage in chronic progressive kidney diseases is due to the increasing incidence of chronic kidney disease in children. The article presents our own scientific results on the clinical and paraclinical characteristics of chronic kidney disease in children and the development of pathogenetic markers for the diagnosis and prognosis of chronic kidney disease in childhood. Based on the assessment of risk factors for progression, inflammatory mediators and fibrogenesis, modern pathogenetic approaches to the early diagnostics of chronic kidney disease in children are scientifically substantiated. The study demonstrates the high diagnostic value of assessing the kidney injury molecule 1 (KIM-1), vascular endothelial growth factor - VEGF, monocyte chemoattractant protein-1 (MCP-1) in combination with the level of interleukin 18 (IL-18) for identifying the initial stages of chronic kidney disease in childhood.
Supporting agencies: The study was carried out according to research carried out within the framework of the State assignment: "Scientific and methodological substantiation of modern technologies for early diagnosis and prevention of chronic progressive kidney diseases in children; forecasting the course and outcomes of the disease" (056-00075-24-00) 2024-2026, NQAF-2024-0006
About the Authors
S. A. Chesnokova
Orenburg State Medical University
Russian Federation
Russian Federation
460000, Orenburg
A. A. Vyalkova
Orenburg State Medical University
Russian Federation
Russian Federation
460000, Orenburg
References
1. Papayan A.V, Savenkova N.D. Clinical nephrology of childhood. Manual for doctors. Levsha, SPb. 2008; 600 (in Russ)
2. Vyalkova A.A., Chesnokova S.A., Plotnikova S.V., Atyakshin D.A., N.O. Davydova. Early diagnosis and prognosis of the course of tubulointerstitial kidney disease in children. Pediatriya. Vostochnaya Evropa. 2024; 12 (2); 243-253 (in Russ) DOI: 10.34 883/pi.2024.12.2.003
3. Chesnokova S.A., Vyalkova A.A. Pathogenetic markers for diagnosis and prognosis of chronic kidney disease in children. Rossijskij vestnik perinatologii i pediatrii. 2021; 66:(3), 62-69 (in Russ) DOI: 10.21508/1027-4065-2021-66-3-62-69
4. Kursova T.S., Morozov S.L., Piruzieva O.R., Bayko S.V. Predictors of progression of chronic kidney disease in children with Cakut. Medicinskij opponent. 2024; 2(26): 59-64 (in Russ)
5. Bagnasco S.M., Rosenberg A.Z. Biomarkers of Chronic Renal Tubulointerstitial Injury. J Histochem Cytochem. 2019; 67(9): 633-641. DOI: 10.1369/0022155419861092
6. Abdurashitova D. I., Nurmatov Sh. Zh., Yusupov A. F., Yuldashev A. A., Aidarov Z. A. Interleukins and their role in the progression of chronic kidney pathology. The Scientific Heritage. 2020; 48(2): 38-42 (in Russ) DOI: 10.51350/zdravkg20219311180
7. Sedashkina О.A., Kolsanov A.V. Ultrasound predictors of chronic kidney disease in children. Sibirskij zhurnal klinicheskoj i eksperimental'noj mediciny. 2025; 40(1): 59-68 (in Russ) DOI: 10.29001/2073-8552-2025-40-1-59-68
8. Pechkurov D.V., Polkanova V.A., Voronina E.N., Poretskova G.Yu. Early diagnosis of chronic kidney disease in children: problems and solutions. Prakticheskaya medicina. 2022; 20(1): 14-20 (in Russ).
9. Mukhtarova A.V., Batyushin M.M., Sinelnik Е.А., Antipova N.V. Role of MCP-1 in the development of tubulointerstitial fibrosis in patients with primary chronic glomerulonephritis. Nephrologija. 2021; 25(5): 92-98 (in Russ) DOI: 10.36485/1561-6274-2021-25-5-92-98
10. Morozova O.L., Morozov D.A., Maltseva L.D., Lakomova D.Yu., Morozov D.D., Palatova T.V. et al. Urinary indicators of inflammation and fibrosis in children with congenital uropathies. Pediatria imeni G.N. Speranskogo. 2018; 97 (5): 19-27 (in Russ)
11. Karimdzhanov I.A., Yusupova G.A., Iskanov G.Kh., Israilova N.A. Arterial hypertension as a risk factor for the development of chronic kidney disease in children with congenital anomalies of the kidneys and urinary tract VAMP/Cakut and its correction. Nefrologija. 2024; 28 (1); 43-49 (in Russ) DOI: 10.36485/1561-6274-2024-28-1-43-49
12. Chazova I.E., Kislyak O.A., Podzolkov V.I., Bragina A.E., Sivakova O.A., Solntseva T.D., et al. Arterial hypertension and chronic kidney disease: consensus on patient management. Sistemnye gipertenzii. 2023; 20(1): 5-19 (in Russ) DOI: 10.38109/2075-082X-2023-1-5-19
13. Morozov S.L., Dlin V.V. Infections of the urinary system in children: management tactics. Pediatriya (Consilium Medicum). 2018; 2: 62–67 (in Russ.) DOI: 10.26442/2413-8460_2018.2.62-67
14. Karmakova Т.А., Sergeeva N.S., Kanukoev К.Yu., Alekseev B.Ya., Kaprin А.D. Kidney injury molecule 1 (KIM-1): a multifunctional glycoprotein and biological marker (review). Sovremennye tehnologii v medicine. 2021; 13(3): 64–80. (in Russ) DOI: 10.17691/ stm2021.13.3.08
15. Safina E.V., Plotnikova I.A., Zelentsova V.L., Bazarnyi V.V., Grushina N.G. Clinical and laboratory markers of structural and functional disorders in the formation of chronic kidney disease in young children, treatment effectiveness. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2024; 69(4): 70-78 (in Russ) DOI: 10.21508/1027-4065-2024-69-4-70-78
16. Bayko S.V., Kulakova E.N., Aksenova M.E., Shumykhina M.V., Nastausheva T.L. Determination of glomerular filtration rate in children and adolescents: theoretical and practical aspects. Nefrologiya i dializ. 2024; 26(2): 186-203 (in Russ) DOI: 10.28996/2618-9801-2024-2-186-203
17. Smirnowa N.N., Galkina O.V., Novikova V.P., Prokopyeva N.E. Modern biomarkers of renal damage in pediatrics. Nefrologija. 2019; 23(4): 12-118 (in Russ.) DOI: 10.24884/1561-6274-2019-23-4-112-118
18. Makarova T.P., Ishbuldina A.V. Cytokines and progressive chronic kidney disease in children. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2021; 66(4): 25-31. (in Russ.) DOI: 10.21508/1027-4065-2021-66-4-25-31
Review
For citations:
Chesnokova S.A., Vyalkova A.A. Diagnostic significance of inflammation and fibrogenesis mediators in chronic kidney disease in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2026;71(1):64-73. (In Russ.) https://doi.org/10.21508/1027-4065-2026-71-1-64-73
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