The health status of adolescent girls with elevated dehydroepiandrosterone sulfate levels
https://doi.org/10.21508/1027-4065-2014-59-5-8-17
Abstract
Objective: to reveal the specific features of somatic, reproductive, and mental health in adolescent girls with elevated dehydroepiandrosterone (DHEA) sulfate levels. One hundred and fifty-nine adolescent girls aged 15 to 18 years from Novosibirsk were examined. A set of studies encompassed clinical examination and examinations by a pediatrician and a gynecologist, abdominal and small pelvic ultrasounds, evaluation of the autonomic nervous system, determination of hormonal profiles, and psychological questionnaire survey. Every two girls had elevated DHEA sulfate levels. The girls with hyperandrogenism had most commonly somatic diseases, as well as psychological features, which require early diagnosis and differential clinical observation to reduce the risk of further reproductive dysfunction.
About the Authors
G. A. SkosyrevaRussian Federation
T. I. Ryabichenko
Russian Federation
E. P. Timofeeva
Russian Federation
T. V. Kartseva
Russian Federation
T. G. Kosyanova
Russian Federation
V. G. Selyatitskaya
Russian Federation
A. N. Trunov
Russian Federation
References
1. Гуркин Ю.А. Детская и подростковая гинекология: Руководство для врачей. М: ООО «Медицинское информационное агентство» 2009; 696. (Gurkin Ju.A. Pediatric and Adolescent Gynecology: A Guide for Physicians. M: OOO «Medicinskoe informacionnoe agentstvo» 2009; 696.)
2. Коколина В.Ф. Гинекологическая эндокринология детского и подросткового возраста. М: Медпракти-ка 2005; 340. (Kokolina V.F. Gynecological endocrinology in childhood and adolescence. M: Medpraktika 2005; 340.)
3. Кучма В.Р., Рапопорт И.К. Стратегия «Здоровье и развитие подростков России» как инструмент охраны и укрепления здоровья подростков. Репродуктивное здоровье детей и подростков 2011; 2:11—21. (Kuchma V.R.,Rapoport I.К. The strategy of "Adolescent Health and Development of Russia" as a tool for protection and promotion of adolescent health. Reproduktivnoe zdorov'e detej i podrostkov 2011; 2: 11-21.)
4. Мазипова Л.П. Современные аспекты патогенеза и под-
5. ходы к терапии акне у подростков. Репродуктивное здоровье детей и подростков 2008; 1: 53—58. (Mazitova L.P. Modern aspects of the pathogenesis and approaches to the treatment of acne in adolescents. Reproduktivnoe zdorov'e detej i podrostkov 2008; 1: 53—58.)
6. Мансурова Т.Н., Тухватуллина Л.М. Гиперандроге-ния у девочек-подростков. Практ мед 2008; 7: 66—68. (Mansurova G.N., Tuhvatullina L.M. Hyperandrogenism in adolescent girls. Prakt med 2008; 7: 66—68.)
7. Laroche E., Bricaire L., Christin-Maitre S. Diagnosis and management of amenorrhea in adolescent gir. Arch Pediat 2013; 20: 7: 817-822.
8. Першит Е.В. Сочетаннаяформагиперандрогении: новый взгляд на старую проблему. Медицинские науки 2010; 39: 4: 10—25. (Pershina E.V. Mixed form of hyperandrogenism: a new look at an old problem. Medicinskie nauki 2010; 39: 4: 10-25.)
9. Уварова Е.В. Патогенетические аспекты и современные возможности коррекции гиперандрогенных проявлений у девочек-подростков. Леч врач 2008; 3: 34—43. (Uvarova E.V. Pathogenetic aspects and modern manifestations
10. correction capabilities hyperandrogenic adolescent girls. Lech Vrach2008; 3:34-43.)
11. Хащенко Е.П., Уварова Е.В. Бшоталамическая дисфункция у девочек пубертатного периода. Репродуктивное здоровье детей и подростков 2010; 4: 35—47. (Hashhenko Е.Р, Uvarova E.V. Hypothalamic dysfunction in girls puberty. Reproduktivnoe zdorov'e detej i podrostkov 2010; 4: 35—47.)
12. Хамошина М.Б., Лебедева М.Т., Вахабова М.И. и др. Юве-нильная гинекология: проблемы и перспективы XXI века. Вестник репродуктивного здоровья 2011; 2: 30— 34. (Hamoshina M.B., Lebedeva M.G., Vahabova M.I. et al. Juvenile gynecology: problems and prospects of the XXI century. Vestnik reproduktivnogo zdorov'ja 2011; 2: 30—34.)
13. Gambineri A., Fanelli E, Prontera O. et al. Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on italian high-school students. J Clin Endocrinol Metab 2013; 98: 4: 1641-1650.
14. Sagodi L., Barkai L. Diagnostic difficulties of polycystic ovarian syndrome in adolescent girls. Orv Hetil 2013; 154: 4: 136-142.
Review
For citations:
Skosyreva G.A., Ryabichenko T.I., Timofeeva E.P., Kartseva T.V., Kosyanova T.G., Selyatitskaya V.G., Trunov A.N. The health status of adolescent girls with elevated dehydroepiandrosterone sulfate levels. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(5):77-81. (In Russ.) https://doi.org/10.21508/1027-4065-2014-59-5-8-17