Evaluation of the efficiency of dietary therapy for gastrointestinal food allergy in infants during the first year of life
Abstract
Thirty-nine infants aged 1,5 to 12 months with allergic enteropathy caused by cow's milk protein intolerance were comprehensively examined to evaluate the morphomnctional state of the intestinal mucosa in infants with food allergy in the first year of life and to analyze the efficiency of performed dietary therapy. Along with multiple coprological tests, fecal calprotectm levels were determined in the babies in the course of the disease. The maintained high levels with an unclear tendency towards a reduction in this indicator (/>=(),06) were registered on days 5—7 of hospital stay; calprotectm production was reduced on days 14—17 day during stabilization and relief of clinical symptoms. Ineffective dietary correction was accompanied by preserved clinical symptoms and elevated fecal calprotectm levels. The analysis of the efficiency of treatment has shown that dietary therapy using the infant formula based on the complete hydrolysis of protein with anti-inflammatory lipids causes a reduction in dermal and gastrointestinal manifestations. It has been concluded that fecal calprotectm determination is a non-invasive criterion for the diagnosis of the morphomnctional state of the intestine in infants with gastrointestinal food allergy and allows the evaluation of the efficiency of dietary therapy.
About the Authors
T. A. Shumatova
Pacific State Medical University, Vladivostok
Russian Federation
Russian Federation
N. G. Prikhodchenko
Pacific State Medical University, Vladivostok
Russian Federation
Russian Federation
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Review
For citations:
Shumatova T.A., Prikhodchenko N.G. Evaluation of the efficiency of dietary therapy for gastrointestinal food allergy in infants during the first year of life. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(5):82-86. (In Russ.)
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