Respiratory syncytial virus infection in children with congenital heart defects: Problem relevance and prevention guidelines
Abstract
Congenital heart defects in children are the most important problem in neonatology and pediatrics, by making a significant contribution to the structure of neonatal/infantile mortality and childhood morbidity. Irrespective of the type of a defect, its presence affects hemodynamics and impairs normal vital activity. Children with hemodynamic heart defects belong to a risk group for severe respiratory syncytial (RS) virus infection. Contagion of such patients increases the length of their hospital stay, changes time periods for surgical intervention, complicates a postoperative period, and raises the risk of a fatal outcome. The possibilities of treatment for the infection are limited. Therefore its prevention is put in the forefront; for this purpose, palivizumab, the world's only drug, is used for the passive immunoprevention of RS virus infection in children at risk for its severe form. The drug can reduce in-hospital morbidity and the duration and severity of the disease. The current worldwide protocols for RS virus infection prevention are unified in terms of classifying the patients with congenital heart defects as a category requiring protection. The international and Russian experience with palivizumab could elaborate and propose the guidelines for the prevention of RS viral infection in patients with hemodynamic congenital heart defects, which are given in this paper and have been approved at the congress on Pediatric Cardiology 2014.
About the Authors
E. L. Bockeria
LA. Vorokhobov City Clinical Hospital Sixty-Seven, Moscow
Russian Federation
Russian Federation
E. A. Degtyareva
Children's Infectious Diseases Clinical Hospital Six, Moscow
Russian Federation
Russian Federation
I. A. Kovalev
Research Clinical Institute of Pediatrics, Moscow
Russian Federation
Russian Federation
I. G. Soldatova
N.F. Filatov City Clinical Hospital Thirteen, Moscow
Russian Federation
Russian Federation
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For citations:
Bockeria E.L., Degtyareva E.A., Kovalev I.A., Soldatova I.G. Respiratory syncytial virus infection in children with congenital heart defects: Problem relevance and prevention guidelines. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(5):101-108. (In Russ.)
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