Persistent infections in pediatrics: A modern view on the problem
https://doi.org/10.21508/1027-4065-2017-62-1-5-9
Abstract
The clinical and social impacts of persistent infections remain relevant. The main aspects of this pediatric problem are the epidemiology and pathogenesis of persistent infections, their clinical manifestations, possibilities for their treatment and prevention, and prediction of the active reproduction of infectious agents. The issues of the human body’s interaction of persistent viruses with viruses that cause acute infectious diseases remain inadequately studied. There is no answer to the question as to the nature of this (synergistic, competitive) interaction or lack thereof. It is unclear how the persistent viruses interact with the host genome. The family and interfamily types of persistent infections, which is of key value in infection prevention in not only a baby, but also in a fetus, have not been adequately explored. This paper focuses on the most important and interesting medical and biological aspects of the problem of persistent infections and gives answers to some of them.
About the Authors
A. D. Tsaregorodtsev
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
E. A. Ruzhitskaya
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
L. B. Kisteneva
D.I. Ivanovsky Research Institute of Virology, Honored Academician N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
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Review
For citations:
Tsaregorodtsev A.D., Ruzhitskaya E.A., Kisteneva L.B. Persistent infections in pediatrics: A modern view on the problem. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(1):5-9. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-1-5-9
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