A RARE CASE OF MIXED INFECTION IN A CHILD: YERSINIOSIS-ASTROVIRUS ENTERITIS
Abstract
Intestinal yersiniosis is a sporadic disease for the Republic of Bulgaria, and mixed forms of infection with other pathogens are extremely rare, they occur in severe form with progressive dehydration and development of different complications. Purpose: to present a clinical case of mixed infection – enteritis – caused by Yersinia enterocolitica and Astrovirus, in a 1-year old child hospitalized with acute diarrheal syndrome of infectious genesis to the Varna Hospital for Infectious Diseases. The study used clinico-epidemiological, laboratory data and information from medical documentation. Results. The patient was diagnosed with enteritis caused by Yersinia enterocolitica and Astrovirus, a mixed form of infection. As a result of the treatment, the child quickly recovered, and the control fecal samples did not give rise to pathogenic bacteria and did not show the presence of viral antigens. Conclusion: mixed infections caused by intestinal pathogens represent an actual problem and they are an object of scientific research. We described the clinical case of a mixed infection with a normal course in a medium-severe form, without complications, and it resulted in complete recovery of the patient after a 5-day course of antibiotic therapy.
About the Authors
E. D. Vlkova
Medical University Professor Doctor Paraskev Stoyanov.
Bulgaria
Bulgaria
I. T. Todorov
Medical University Professor Doctor Paraskev Stoyanov.
Bulgaria
Bulgaria
M. D. Gospodinova
Medical University Professor Doctor Paraskev Stoyanov.
Russian Federation
Russian Federation
References
1. Marshall J.A. Mixed Infections of Intestinal Viruses and Bacteria in Humans. In: Polymicrobial Diseases. K.A. Brogden, J.M. Guthmiller ( eds). Washington (DC): ASM Press, 2002; 326.
2. Hori H., Akpedonu P., Armah G., Aryeetey M., Yartey J., Kamiya H., Sakurai M. Enteric pathogens in severe forms of acute gastroenteritis in Ghanaian children. Acta Pediatr Jpn 1996; 38: 672–676.
3. Ayala V.I., Teijaro J.R., Farber D.L., Dorsey S.G., Carbonetti N.H. Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin-Mediated Suppression of Innate Immunity. PLoS ONE 2011; 6(4): e19016. DOI: 10.1371/journal.pone.0019016
4. Di Biase A.M., Petrone G., Conte M.P., Seganti L., Ammendolia M.G., Tinari A., Iosi F., Marchetti M., Superti F. Infection of human enterocyte-like cells with rotavirus enhances invasiveness of Yersinia enterocolitica and Y. pseudotuberculosis. J Med Microbiol 2000; 49: 897–904.
5. Guix S., Caballero S., Villena C., Bartolomé R., Latorre C., Rabella N. et al. Molecular Epidemiology of Astrovirus Infection in Barcelona, Spain. J Clin Microbiol 2002; 40(1): 133–139. DOI:10.1128/JCM.40.1.133–139.2002
6. Bekhtereva M.K., Purin V.I., Panova T.F., Dutova Yu.P., Ivanova V.V. Rare outcome yersiniosis at the teenager. Pediatr 2013; IV(3): 122–124. (in Russ)
7. Sabina Y., Rahman A., Ray R.C., Montet D. Yersinia enterocolitica: Mode of Transmission, Molecular Insights of Virulence, and Pathogenesis of Infection. J Pathog 2011; 2011: 429069. DOI: 10.4061/2011/429069
8. Jochev S. Infectious diseases. Textbook. Medicinsko izdatelstvo Rajkov, 2007; 99–101 (in Bulg)
9. Ceneva G.Ja., Solodovnikova N.Yu., Voskresenskaja E.A. Molecular aspects of Yersinia virulence. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija 2002; 4(3): 248–266. (in Russ)
10. Marinova L., Kurchatova A., Vladimirova N., Georgieva T., Minkova A., Parmakova K. Acute and contagious diseases in Bulgaria in 2015 (Key Epidemiological Indicators). Available from: https://www.ncipd.org/index.php?option=com_docman&view=download&alias=79-analiz-cd-balgariya-2015&category_slug=2015-1&Itemid=1127&lang=bg. (in Bulg)
11. European Centre for Disease Prevention and Control. Annual Epidemiological Report 2016 – Yersiniosis. [Internet]. Stockholm: ECDC, 2016; https://ecdc.europa.eu/en/publicationsdata/yersiniosis-annual-epidemiological-report-2016-2014-data
12. Mankevich R.N., Matush L.I., Lagir G.M. Yersiniosis in children. Educational and methodical manual. Minsk: BGMU 2018; 31. (in Russ)
13. Cohen M.B. Etiology and mechanisms of acute infectious diarrhea in infants in the United States. J Pediatr 1991; 118: S34–39.
14. Dikov I.N. Infectious diseases. Textbook. Sofia: Znanie 2006; 307. (in Bulg)
15. Uchaykin V.F., Cherednichenko T.V., Konovalova L.I. Yersinia hepatitis in children. Detskie infekcii 2011; 4: 17–20. (in Russ)
16. Bosch A., Pintó R.M., Guix S. Human Astroviruses. Clin Microbiol Rev 2014; 27(4): 1048–1074. DOI: 10.1128/CMR.00013-14
17. Kurtz J.B., Lee T.W., Craig J.W., Reed S.E. Astrovirus infection in volunteers. J Med Virol 1979; 3: 221–230.
18. Wunderli W., Meerbach A., Guengoer T., Berger C., Greiner O., Caduff R. et al. Correction: Astrovirus Infection in Hospitalized Infants with Severe Combined Immunodeficiency after Allogeneic Hematopoietic Stem Cell Transplantation. PLoS ONE 2011; 6(11): e27483. DOI: 10.1371/journal.pone.0027483
19. Jakab F., Peterfai J., Verebeli T., Meleg E., Banyai K., Mitchell D.K., Szucs G. Human astrovirus infection associated with childhood intussusception. Pediatr Inter 2007; 49: 103–105. DOI: 10.1111/j.1442-200X.2007.02293.x
Review
For citations:
Vlkova E.D., Todorov I.T., Gospodinova M.D. A RARE CASE OF MIXED INFECTION IN A CHILD: YERSINIOSIS-ASTROVIRUS ENTERITIS. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(5):98-102. (In Russ.)
Views:
797
Email this article 