Analysis of clinical and immunological parameters in children with joint pathology
https://doi.org/10.21508/1027-4065-2018-63-5-55-59
Abstract
For the purpose of comparative analysis of clinical and immunological parameters in children with juvenile idiopathic arthritis (n=56) and reactive arthritis (n=22) we determined the concentration of individual Th1- (IL-1β, IL-6, INF-γ), Th2- (IL-4) and Th17- associated interleukins (IL-17) in the blood serum. We conducted clinical examination of the patients, taking into account the duration of the disease, the amount of drug therapy and indicators of functional status. The concentration of interleukins in the serum was determined by enzyme immunoassay using ready-made commercial kits. We found that the course of juvenile idiopathic arthritis and reactive arthritis is characterized by a certain unidirectionality of disorders in the system of Th1-and Th2-associated cytokines. There were indentified key correlations between the studied interleukins for the diseases concerned. We proposed an interrelated analysis of immunological activity indicators, which allowed simplifying the differential diagnostics of articular form of juvenile idiopathic arthritis and reactive arthritis.
Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
About the Authors
A. Yu. Spivakovskaya
Razumovskiy Saratov State Medical University
Russian Federation
Russian Federation
Yu. M. Spivakvskiy
Razumovskiy Saratov State Medical University
Russian Federation
Russian Federation
Yu. V. Chernenkov
Razumovskiy Saratov State Medical University
Russian Federation
Russian Federation
References
1. Hofer M.F., Mouy R., Prieur A.M. Juvenile idiopathic arthritides evaluated prospectively in a single center according to the Durban criteria. J Rheumatol 2001; 28(5): 1083–1090.
2. Цурикова Н.А., Лигостаева Е.А., Жолобова Е.С. Сравнительная эффективность и безопасность нестероидных противовоспалительных препаратов в лечении ранних олигоартритов у детей. Педиатрия. Журнал имени Г.Н. Сперанского 2015; 94(2): 125–130. DOI:10.24110/0031- 403X-2015-94-2-125-130 [Curikova N.A., Ligostaeva E.A., Zholobova E.S. Comparative effectiveness and safety of non-steroidal anti-inflammatory drugs in the treatment of early oligoartritis in children. Pediatria. Journal named after G.N.Speransky 2015; 94 (2): 125–130. DOI:10.24110/0031-403X-2015-94-2-125-130 (in Russ)]
3. Давлетгильдеева З.Г., Карибаева Д.О., Каматаев А.С., Балтабай Р.Р., Кожин А.Б., Кенжебеков А.О., Бейкутулы Н. Особенности современного течения реактивных артритов у детей. Молодой ученый 2016; 6: 278–280. [Davletgil’deeva Z. G., Karibaeva D. O., Kamataev A.S., Baltabaj R.R., Kozhin A.B., Kenzhebekov A.O., Bejkutuly N. Features of the current course of reactive arthritis in children. Molodoj uchenyj 2016; 6: 278–280. (inRuss)]
4. Беляева Л.М., Хрусталева Е.К., Колупаева Е.А., Чижевская И.Д., Довнар-Запольская О.Н., Коваленко Т.В. Характеристика клинико-иммунологических показателей у детей с ювенильным ревматоидным артритом и ювенильной склеродермией. Кардиология в Беларуси 2009; 4(3):55–63. [Beljaeva L.M., Hrustaleva E.K., Kolupaeva E.A., Chizhevskaja I.D., Dovnar-Zapol’skaja O.N., Kovalenko T.V. Characteristics of clinico-immunological indices of children with juvenile rheumatoid arthritis and juvenile scleroderma. Kardiologiya v Belarusi 2009; 4(3): 55–63. (in Russ)]
5. Литвицкий П.Ф. Система иммунобиологического надзора и иммунопатологические синдромы. Вопр соврем педиатр 2007;6(3):63–70. [Litvitsky P.F. immunobiological control system and immunopathological syndromes. Vopr Sovrem Pediatr 2007; 6(3): 63–70. (in Russ)]
6. Федеральные клинические рекомендации по оказанию медицинской помощи детям с ювенильным артритом. Москва: Союз педиатров России 2013; 33. [Federal clinical guidelines for the provision of medical care to children with juvenile arthritis. Moscow: Soyuz pediatrov Rossii 2013; 33. (in Russ)]
7. Баранов А.А. Федеральные клинические рекомендации по оказанию помощи детям с реактивным артритом. М 2015; 19. [Baranov, A.A. Federal clinical guidelines for assisting children with reactive arthritis. Moscow 2015; 19. (in Russ)]
8. Raggatt L.J., Partridge N.C. Cellular and Molecular mechanisms of bone remodeling. J Biol Chem 2010; 285(33): 25103–25108. DOI: 10.1074/jbc.R109.041087.
9. Хаитов, Р.М., Игнатьева Г.А., Сидорович И.Г. Иммунология. М: Медицина 2000; 430. [Haitov R.M., Ignat’eva G.A., Sidorovich I.G. Immunology. Moscow: Meditsina 2000; 430. (in Russ)]
10. Хаитов Р.М., Ильина Н.И. Аллергология и иммунология. Национальное руководство. М: ГЭОТАР-Медиа 2009; 636. [Haitov R.M., Il’ina N.I. Allergology and Immunology. National leadership. Moscow: GEOTAR-Media 2009; 636. (in Russ)]
Review
For citations:
Spivakovskaya A.Yu., Spivakvskiy Yu.M., Chernenkov Yu.V. Analysis of clinical and immunological parameters in children with joint pathology. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(6):55-59. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-5-55-59
Views:
940
Email this article 