Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents
https://doi.org/10.21508/1027-4065-2019-64-1-7-14
Abstract
The greatest threat to the health of the children exposed to radiation or born from irradiated parents after the accident at the Chernobyl NPP is the risk of developing stochastic radiation-induced pathology: genetic diseases, undifferentiated mental retardation, malignant neoplasms, etc. According to the provisions of international organizations (UNSCEAR, BEIR and ICRP), these effects can be caused by any dose, even a small one.
Stochastic effects, which are currently associated with ionizing radiation, occur as mutations and then they are expressed to the final clinical manifestations (oncological, genetic pathology) as hidden genome damage. The article describes the complex of risk factors of developing radiation-induced diseases, namely, the phenomenon of genomic instability, the system of genomic DNA repair as a mechanism of anti-mutagenic protection, characteristic of gene expression of the TP53 gene network, immunological predictors of the risk of developing radiation-induced diseases for early diagnosis of the pathology and minimization of the effects of ionizing radiation.
Keywords
children,
ionizing radiation,
radiation-induced stochastic diseases,
medical and biological risk factors
Supporting agencies: Ministry of Health of Russia
About the Authors
L. S. Baleva
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow.
Russian Federation
Moscow.
A. E. Sipyagina
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow.
Russian Federation
Moscow.
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Review
For citations:
Baleva L.S., Sipyagina A.E. Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(1):7-14. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-1-7-14
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