Lyell’s syndrome in children – clinical features, treatment
https://doi.org/10.21508/1027-4065-2019-64-1-99-102
Abstract
Lyell’s syndrome is one of the most serious diseases of a toxic-allergic nature and it presents a real threat to children life. The article presents literature data and clinical observations of Lyell’s syndrome in children, the etiological cause of which was medication, often used in pediatric practice for viral infections – 0.05% eye bonafton ointment, paracetamol. Based on the analysis of literature data and our own observations, we propose the algorithm of therapeutic measures in children with Lyell’s syndrome, which includes the administration of glucocorticoids, immunoglobulins for intravenous administration, hyposensitizing agents, correction of water and electrolyte balance, local treatment, etc.
About the Authors
G. A. KharchenkoRussian Federation
Astrakhan.
O. G. Kimirilova
Russian Federation
Astrakhan.
References
1. Harr T., French L.E. Toxic epidermal necrolysis and Stevens-Johnson Syndrome. Orphanet J Rare Dis 2010; 5: 39. DOI: 10.1186/1750-1172-5-39
2. Mezhirova N.M., Baeva S.I., Azarokova А.M. Features course and treatment of toxic epidermal necrolysis. Meditsina neotlozhnyh sostoyanii 2011; 5: 36–38. (in Russ)
3. Grigoriev D.V. Еxudative erythema multiforme, Stevens-Johnson syndrome and syndrome Layella – modern interpretation problems. Russkiy meditsinskii zhurnal 2013; 22: 1073–1083. (in Russ)
4. Haitova R.M., Il’ina I.N. Allergology and immunology. Moscow: GEO-TAR-Media, 2009; 532 (in Russ)
5. Ilyinа N.I., Latysheva T.V. Drug allergy, clinical guidelines. Rossiyskiy allergologicheskii zhurnal 2013; 5: 27–40. (in Russ)
6. Tan S.K., Tay V.K. Profile and Pattern of Stevens-Johnson Syndrome and Toxic Epidermal Necrolisis in a General Hospital in Singapore: Treatment outcomes. Acta Derm Venerol 2012; 92: 62–66. DOI: 10.2340/00015555-1169
7. Zryachkin N.I. Lyell’s syndrome in a child 9 months’. Pediatriya 2011; 6: 152–153 (in Russ)
8. Albanova V.I., Brunova O.Yu., Korsunskii A.A. Toxic epidermal necrolysis in children. Rossiyskiy zhurnal kozhnykh i venericheskikh boleznei 2013; 5: 25–30 (in Russ)
9. Varsheva I.I, Hashkina L.A. Toxic epidermal necrolysis: сlinical features and treatment. Sibirskiy meditsinskiy zhurnal (Serbian Medical Journal) 2014; 6: 130–132 (in Russ)
10. Bachot N., Revuz J., Roujeau J.-C. Intravenous immunoglobulin treatment for Stevens-Jonhson syndrome and toxic epidermal necrolysis. Arch Dermatol 2003; 139: 33–36.
11. Prins C., Kerdel F.A., Padilla S., Hunziker T., Chimenti S., Viard I. et al. Treatment of toxic epirermal necrolysis with high-dose intravenous immunoglobulins. Arch Dermatol 2003; 139: 26–32.
12. Stella M., Cassano P., Bollero D., Clemente A., Giorio G. Toxic epidermal necrolysis treated with intravenous high-dose immunoglobulins: our experience. Dermatol 2001; 203(1): 45–49.
13. Trent J.T., Kirsner R.S., Romanelli P., Kerdel F.A. Analysis of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis using SCORTEN. Arch Dermatol 2003; 139: 39–43.
14. Kudin A.P., Ocheretnii M.D., Zagorskii V.S., Bylina M.A., Maita M.P., Savitskii D.V., Matush L.I. Еxperience with the use of intravenous immunoglobulin in the syndrome of Lyell’s children. Med zhurn Belorusskogo med universiteta (Minsk) 2013; 3(45): 145–147. (in Belarus)
15. Metry D.W., Jung P., Levy M.L. Use of intravenous immunoglobulin in children with Stevens-Johnson syndrome and toxic epidermal necrolysis: seven cases and review of literature. Pediatrics 2003; 112(6): 1430–1436.
Review
For citations:
Kharchenko G.A., Kimirilova O.G. Lyell’s syndrome in children – clinical features, treatment. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(1):99-102. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-1-99-102