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Российский вестник перинатологии и педиатрии

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Современный взгляд на лечение хронического гепатита С у детей и подростков

https://doi.org/10.21508/1027-4065-2019-64-6-11-19

Аннотация

Цель статьи – обобщающий обзор подходов к лечению инфекции, вызванной вирусом гепатита С (HCV), у детей и подростков. Статья посвящена вопросам, затрагивающим показания, противопоказания и оптимальные схемы лечения у детей и подростков с хронической HCV-инфекцией.

Во всем мире 13,2 (11,5–21,2) млн детей в возрасте от 1 до 15 лет инфицированы HCV. У детей, как правило, хроническая HCV-инфекция более вялотекущая, чем у взрослых; внепеченочные проявления преимущественно в виде субклинического гипотиреоза и аутоиммунного тиреоидита встречаются соответственно в 11 и 5,6% случаев. Риск развития цирроза печени у детей с хронической HCV-инфекцией составляет от 1 до 4%, в то время как мостовидный фиброз и тяжелое воспаление печени описаны примерно у 15%. В статье рассматриваются вопросы терапии: цели, конечные точки, показания, противопоказания и оптимальный режим лечения у детей с хронической HCV-инфекцией. Представлены рекомендации, сформулированные Европейским обществом детских гастроэнтерологов, гепатологов и нутрициологов (ESPGHAN).

Заключение. Хроническая HCV-инфекция у детей в целом протекает в доброкачественной форме, однако лечение заболевания требуется для достижения успеха в деле ликвидации гепатита С.

Об авторе

Г. В. Волынец
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России
Россия

Волынец Галина Васильевна – д.м.н., гл. науч. сотр. отдела гастроэнтерологии Научно-исследовательского клинического института педиатрии им. академика Ю.Е. Вельтищева

Москва



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Рецензия

Для цитирования:


Волынец Г.В. Современный взгляд на лечение хронического гепатита С у детей и подростков. Российский вестник перинатологии и педиатрии. 2019;64(6):11-19. https://doi.org/10.21508/1027-4065-2019-64-6-11-19

For citation:


Volynets G.V. A modern view on the treatment of chronic hepatitis C in children and adolescents. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(6):11-19. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-6-11-19

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