Thrombotic complications in patients with congenital heart defects after cardiac surgery
L. A. Gandaeva,
E. N. Basargina,
K. Z. Zubkova,
O. B. Gordeeva,
Yu. V. Derevnina,
O. P. Zharova,
N. V. Zhurkova,
N. A. Sdvigova,
R. F. Tepaev,
V. A. Lastovka https://doi.org/10.21508/1027-4065-2020-65-1-110-115
Abstract
The thrombotic complications develop in 3,6–13% of children with congenital heart defects in the postoperative period, which makes the diagnosis and prevention of thrombosis relevant. Permanent risk factors include the carriage of mutations/polymorphic variants of genes, leading to an imbalance in the procoagulant and anticoagulant hemostatic systems. In some cases, children after cardiac surgery are prescribed anticoagulants, warfarin is the most commonly used vitamin K antagonist, which can cause warfarin-associated skin necrosis as a result of vascular microthrombosis of the microvasculature. We provide our own observation – a case of thrombosis and warfarin-associated skin necrosis in a child after a multi-stage correction of congenital heart defect on the background of indirect anticoagulant therapy.
About the Authors
L. A. Gandaeva
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
E. N. Basargina
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
K. Z. Zubkova
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
O. B. Gordeeva
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Yu. V. Derevnina
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
O. P. Zharova
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
N. V. Zhurkova
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
N. A. Sdvigova
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
R. F. Tepaev
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
V. A. Lastovka
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Gandaeva L.A., Basargina E.N., Zubkova K.Z., Gordeeva O.B., Derevnina Yu.V., Zharova O.P., Zhurkova N.V., Sdvigova N.A., Tepaev R.F., Lastovka V.A. Thrombotic complications in patients with congenital heart defects after cardiac surgery. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(1):110-115. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-1-110-115
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