Fever in children: review of national and international studies and clinical guidelines
https://doi.org/10.21508/1027-4065-2020-65-3-153-159
Abstract
Fever in children is one of the most common reasons for seeking medical care and use of antipyretic drugs. The reasons can be various. It is extremely important for the pediatrician to find the cause of the fever and prescribe adequate therapy. Antipyretic drugs are symptomatic, they only relieve the condition of the child and improve the quality of life. The article reviews national and international studies and clinical guidelines of professional communities on fever in children. Currently, only ibuprofen and paracetamol fully meet the safety and efficacy criteria, and they are recommended for use in pediatric practice as antipyretic drugs.
About the Authors
E. E. LokshinaRussian Federation
O. V. Zaytseva
Russian Federation
S. V. Zaytseva
Russian Federation
References
1. Lokshina E.E., Zaytseva O.V., Zaytseva S.V. Therapy for feverishness in infants with acute respiratory diseases: current aspects. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2009; 54(6): 107–114. (in Russ.)
2. Lokshina E.E. A modern view of rational therapy for fever in children. RMJ (Russian Medical Journal) 2013; 21(2):103–107. (in Russ.)
3. Baranov A.A., Tatochenko V.K., Bakradze M.D. Febrile child. Diagnostic and treatment protocols. Moscow: Union of pediatricians of Russia, 2017; 320. (in Russ.)
4. Voroncov I.M., Mazurin A.V. Propaedeutics of childhood diseases. Saint-Petersburg: Foliant, 2010; 1008. (in Russ.)
5. Consolini D.M. Fever in Infants and Children. 2018. https://www.msdmanuals.com/home/children-s-health-issues/symptoms-in-infants-and-children/fever-in-infants-andchildren (Accessed on January 30, 2020)
6. Khramtsova E.G., Muraveva N.N., Kliorina T.A., Akim A.A. Long subfebrile in childhood: modern aspects of diagnostic search. Pediatr 2013; 4(2): 97–105. (in Russ.)
7. Hui C., Neto G., Tsertsvadze A., Yazdi F., Tricco A.C., Tsouros S. et al. Diagnosis and management of febrile infants (0–3 months). Evid Rep Technol Assess (Full Rep) 2012; 205: 1–297. 8. https://effectivehealthcare.ahrq.gov/products/febrile-infants-diagnosis-management/research (Accessed on January 30, 2020)
8. Niven D.J., Gaudet J.E., Laupland K.B., Mrklas K.J., Roberts D.J., Stelfox H.T. Accuracy of peripheral thermometers for estimating temperature: a systematic review and meta-analysis. Ann Intern Med 2015; 163: 768. DOI: 10.7326/M15-1150
9. Ward M.A., Hannemann N.L. Fever: Pathogenesis and treatment. In: Feigin and Cherry’s Textbook of Pediatric Infec tious Diseases, 8th ed, Cherry J.D., Harrison G., Kaplan S.L. et al. (eds). Elsevier, Philadelphia, 2018; 52.
10. Schmitt B.D. Fever in childhood. Pediatrics 1984; 74: 929.
11. Infancy: First week visit (3 to 5 days). In: Bright Futures. Guidelines for Health Supervision of Infants, Children, and Adolescents, 4th ed, Hagan J.F., Shaw J.S., Duncan P.M. (eds). American Academy of Pediatrics, Elk Grove Village, 2017; 361.
12. National Institute for Health and Care Excellence. Feverish illness in children (CG160). 2013. http://guidance.nice.org.uk/CG160 (Accessed on January 30, 2020).
13. Paes B.F., Vermeulen K., Brohet R.M., van der Ploeg T., de Winter J.P. Accuracy of tympanic and infrared skin thermometers in children. Arch Dis Child 2010; 95: 974. DOI: 10.1136/adc.2010.185801
14. Freed G.L., Fraley J.K. Lack of agreement of tympanic membrane temperature assessments with conventional methods in a private practice setting. Pediatrics 1992; 89: 384.
15. Hay A.D., Peters T.J., Wilson A., Fahey T. The use of infrared thermometry for the detection of fever. Br J Gen Pract 2004; 54: 448.
16. Ward M.A., Hannemann N.L. Fever: Pathogenesis and treatment. In: Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, 8th ed, Cherry J.D., Harrison G., Kaplan S.L. et al. (eds). Elsevier, Philadelphia, 2018; 52.
17. Titus M.O., Hulsey T., Heckman J., Losek J.D. Temporal artery thermometry utilization in pediatric emergency care. Clin Pediatr (Phila) 2009; 48: 190. DOI: 10.1177/0009922808327056
18. Teller J., Ragazzi M., Simonetti G.D., Lava S.A. Accuracy of tympanic and forehead thermometers in private paediatric practice. Acta Paediatr 2014; 103 :e80. DOI: 10.1111/apa.12464
19. Non-contact thermometers for detecting fever: A review of clinical effectiveness. Rapid Response Report: Summary with Critical Appraisal. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. 2014. https://www.cadth.ca/sites/default/files/pdf/htis/nov-2014/RC0610%20Non-contact%20Thermometers%20Final.pdf (Accessed on January 30, 2020)
20. Teran C.G., Torrez-Llanos J., Teran-Miranda T.E., Balderrama C., Shah N.S., Villarroel P. Clinical accuracy of a non-contact infrared skin thermometer in paediatric practice. Child Care Health Dev 2012; 38: 471. DOI: 10.1111/j.1365-2214.2011.01264.x
21. FUS Team, Cincinnati Children’s Hospital Medical Center: Evidence based clinical care guideline for fever of uncertain source in infants 60 days of age or less. 2010. http://www.cincinnatichildren.org/svc/alpha/h/healthpolicy/evbased/default.htm. (Accessed on January 30, 2020)
22. Gattorno M. Autoinflammatory diseases in children. Voprosy sovremennoi pediatrii 2014; 13(2): 55–64. (in Russ.)
23. Acute respiratory infections in children: treatment and prevention. The scientific and practical program of Union of pediatricians of Russia. Moscow: International Fund for Maternal and Child Health, 2002; 69. (in Russ.)
24. Federal Clinical Guidelines for Providing Emergency Medical Care for Acute Fever in Children. Ministry of Health of the Russian Federation. Union of Pediatricians of Russia. Russian Society for Emergency Medicine. Moscow, 2015; 10. (in Russ.)
25. National Institute for Health and Clinical Excellence (NICE). Fever in under 5s: assessment and initial management. NICE Clinical Guideline 143. London, UK: NICE, 2019. https://www.nice.org.uk/guidance/ng143 (Accessed on January 30, 2020)
26. Clinical Practice Guidelines of The Royal Children’s Hospital Melbourne: Febrile child. August 2018.
27. https://www.rch.org.au/clinicalguide/guideline_index/Febrile_Child/ (Accessed on January 30, 2020.)
28. Chiappini E., Bortone B., Galli L., de Martino M. BMJ Open 2017; 7: e015404. DOI: 10.1136/bmjopen-2016-015404 1
29. The management of fever in young children with acute respiratory infection in developing countries/ WHO/ ARI/93.90. WHO Geneva, 1993; 17. https://apps.who.int/iris/handle/10665/58266 (Accessed on January 30, 2020.)
30. Hay A.D., Redmond N.M., Costelloe C., Montgomery A.A., Fletcher M., Hollinghurst S. et al. Paracetamol and Ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. Health Technol Assess. 2009; 13(27): iii–iv, ix–x, 1–163. DOI: 10.3310/hta13270
31. Geppe N.A., Zaytseva O.V. Ideas about the mechanisms of fever in children and the principles of antipyretic therapy. RMJ (Russian Medical Journal) 2003; 11(1): 31–37. (in Russ)
Review
For citations:
Lokshina E.E., Zaytseva O.V., Zaytseva S.V. Fever in children: review of national and international studies and clinical guidelines. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(3):153-159. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-3-153-159