Clinical and diagnostic significance of urinary neutrophil gelatinase-associated lipocalin-2 measurement in children with microbial inflammatory kidney and urinary tract diseases
Abstract
Objective: to study the clinical and diagnostic significance of urinary neutrophil gelatinase-associated lipocalin-2 (NGAL) measurement in children with urinary tract infection (я=15) and pyelonephritis (я=15). The patients' age was 1 to 16 years (mean age, 7.32+4.52 years). The diagnosis was verified on the basis of clinical and laboratory findings and medical history and instrumental examination data. Urinary NGAL levels were measured by enzyme immunoassay (a Bio\fendor Laboratory Medicine kit) and calculated with reference to mg of creatinine. Urinary NGAL levels were established to depend on the degree of renal parenchymal damage. The investigation showed a relationship between the excretion of NGAL during the acute phase of pyelonephritis and the detection of renal scarring, as evidenced by statistical DMCA nephroscintigraphy. The acute pyelonephritis group exhibited a moderate direct correlation between the renal excretion of NGAL and the degree of leukocytosis and the blood levels of C-reactive protein. The findings allow recommendations for measuring urinary NGAL levels as an additional noninvasive marker for the early detection of renal parenchymal damage.
About the Authors
A. V. Eremeeva
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
V. V. Dlin
Acad. Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow
Russian Federation
Russian Federation
A. A. Korsunsky
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
S. B. Orekhova
G.N. Speransky City Children's Clinical Hospital Nine, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Eremeeva A.V., Dlin V.V., Korsunsky A.A., Orekhova S.B. Clinical and diagnostic significance of urinary neutrophil gelatinase-associated lipocalin-2 measurement in children with microbial inflammatory kidney and urinary tract diseases. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(6):60-65. (In Russ.)
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