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Российский вестник перинатологии и педиатрии

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Современная стратегия диагностики и лечения семейной гетерозиготной гиперхолестеринемии у детей

https://doi.org/10.21508/1027-4065-2020-65-4-27-40

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Аннотация

Семейная гетерозиготная гиперхолестеринемия — наследуемое по аутосомно-доминантному типу заболевание, характеризующееся высоким уровнем в крови холестерина липопротеинов низкой плотности, что приводит к началу атеросклеротического поражения сосудов уже в детском возрасте и развитию инфаркта миокарда на втором—третьем десятилетии жизни. Семейная гиперхолестеринемия остается малоизвестным заболеванием в клинической практике педиатра. Это ведет к запоздалой диагностике и позднему началу терапии. Заболевание длительно протекает бессимптомно, в связи с чем его выявление составляет менее 1% случаев. Освещены генетические аспекты заболевания. Изложены критерии диагностики семейной гетерозиготной гиперхолестеринемии у детей, представлены различные варианты скрининга. Рассмотрены возможности ранней диагностики сосудистого поражения атеросклеротического генеза. Освещена стратегия ведения пациентов с семейной гетерозиготной гиперхолестеринемией, обсуждаются возможности немедикаментозной и медикаментозной терапии. Изложены показания к назначению, эффективность и безопасность применения статинов как основного класса препаратов для лечения заболевания.

Об авторе

И. В. Леонтьева
ОСП Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России
Россия

Леонтьева Ирина Викторовна — доктор медицинских наук, проф., главный научный сотрудник отдела детской кардиологии и аритмологии.

125412 Москва, ул. Талдомская, 2



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Для цитирования:


Леонтьева И.В. Современная стратегия диагностики и лечения семейной гетерозиготной гиперхолестеринемии у детей. Российский вестник перинатологии и педиатрии. 2020;65(4):27-40. https://doi.org/10.21508/1027-4065-2020-65-4-27-40

For citation:


Leontyeva I.V. Modern strategy of diagnosis and treatment of children with heterozygous familial hypercholesterolemia. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(4):27-40. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-4-27-40

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ISSN 1027-4065 (Print)
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