Clinical characteristics and features of the monocytic link of innate immunity in children with extremely low body weight and severe bronchopulmonary dysplasia
https://doi.org/10.21508/1027-4065-2021-66-2-56-61
Abstract
In order to assess the immunity indicators of early premature children born in the period from 22 to 27 weeks the researchers conducted a dynamic examination of 24 newborns: 11 children with severe bronchopulmonary dysplasia (Group 1) and 13 children without bronchopulmonary dysplasia (Group 2). They used flow cytometry to determine monocyte counts (CD14+CD64+, CD14+HLA-DR+, CD11b+CD14+).
The authors determined the peculiarities of the immune status of children with severe bronchopulmonary dysplasia. They found that the spectrum of monocyte-macrophage protection factors of the children with extremely low body weight was significantly reduced due to a decrease in cell adhesion and migration of the (CD14+CD64+) cells to the inflammation site, as well as the presentation of infectious pathogens – viruses or bacteria (CD14+HLA-DR+), which may be the reason for the development of bacterial complications and prolonged course of the inflammatory process, one of the main factors in the development of severe bronchopulmonary dysplasia.
The revealed features of the immune status in infants with bronchopulmonary dysplasia can be used to evaluate the effectiveness of the therapy, which dictates the need for further studies.
Keywords
Supporting agencies: The study was carried with financial support from the Ministry of Education and Science, grant of the President of the Russian Federation № MK-1140.2020.7.
About the Authors
L. S. Ustyantseva
Ural Research Institute of Maternity and Infancy Welfare
Russian Federation
Russian Federation
Ekaterinburg
G. N. Chistyakova
Ural Research Institute of Maternity and Infancy Welfare
Russian Federation
Russian Federation
Ekaterinburg
I. I. Remizova
Ural Research Institute of Maternity and Infancy Welfare
Russian Federation
Russian Federation
Ekaterinburg
V. E. Ryumin
Ural Research Institute of Maternity and Infancy Welfare
Russian Federation
Russian Federation
Ekaterinburg
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Review
For citations:
Ustyantseva L.S., Chistyakova G.N., Remizova I.I., Ryumin V.E. Clinical characteristics and features of the monocytic link of innate immunity in children with extremely low body weight and severe bronchopulmonary dysplasia. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(2):56-61. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-2-56-61
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