Prevention of Diaper Irritation and Redness in Newborns and Infants: Results from the Dexpan Plus® Baby Clinical Study
https://doi.org/10.21508/1027-4065-2021-66-2-130-137
Abstract
Diaper dermatitis is a common disease in children under 2 years of age; its prevention is based on proper care, hygiene, frequent diaper changes, aeration, gentle skin cleansing and the optimal choice of cosmetics. The authors conducted an observational study to investigate the effect of Dexpan Plus® Baby cream in newborns and infants to prevent diaper-induced irritation and redness of the skin. Dexpan Plus® Baby Cream was applied to clean and dry skin in the groin area with each diaper change for 30 days. The study included 30 children from 3 to 12 months old with skin phototypes I – III according to the Fitzpatrick scale. When caring for children, their parents regularly used disposable diapers (at least 5 times at the daytime and 2 times at night).
According to the results of the study, 93.3% of children had no diaper dermatitis on the diaper dermatitis scale. According to the assessment of doctors and parents, 100% of children had “good” and “very good” tolerance with regular use of the cream. Dexpan Plus® Baby Cream has been shown to be safe and it can be recommended for newborns and infants to prevent diaper-induced irritation and redness of the skin. Parents were satisfied with the cream, at the final visit 100% of parents positively assessed the cosmetic effects of the cream, they fully agreed that the cream was suitable for sensitive skin of a child, it softened the skin, had a protective effect against redness and moisturizing effect, the cream was easy to apply; 93% of parents completely agreed with the statement that the cream reduced skin redness.
About the Authors
E. S. Keshishyan
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
E. S. Sakharova
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
G. А. Аlyamovskaya
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
N. V. Pavlova
Dr. Reddy’s Laboratories Ltd.
Russian Federation
Russian Federation
Moscow
References
1. Бердникова Е.К. Особенности ухода за кожей у детей раннего возраста. Пеленочный дерматит, причины возникновения, методы лечения. Медицинский совет 2013; 8: 102–105. [Berdnikova E.K, Features of skin care in young children. Diaper dermatitis, causes, treatment methods. Meditsinskiy sovet 2013; 8: 102–105. (In Russ.)]
2. Белоусова Н.А., Горелов А.В., Семеновых Е.Г. Лечение пеленочного дерматита у новорожденных с применением мази Д-Пантенол. Педиатрия. Журнал имени Г.Н. Сперанского 2002; 4: 54–55. [Belousova N.A., Gorelov A.V., Semenovyh E.G. Treatment of diaper dermatitis in newborns using D-Panthenol ointment. Pediatriya. 2002; 4: 54–55. (In Russ.)]
3. Супрун Э.В. Новые подходы к уходу за кожей детей раннего возраста и профилактике дерматита. Современная педиатрия 2018; 5(93): 72–85. [Suprun E.V. New approaches to early childhood skin care and dermatitis prevention. Sovremennaya pediatria 2018; 5(93): 72–85. (In Russ.)] DOI 10.15574/SP.2018.93.72
4. Кешишян Е.С., Сахарова Е.С., Афанасьева Н.В. Пеленочный дерматит. Роль медицинской сестры в патронаже младенца с пеленочным дерматитом. Медицинский совет 2019; 2: 33–37. [Keshishyan E.S., Sakharova E.S., Afanasieva N.V. Diaper dermatitis. The role of a nurse in the care of an infant with diaper dermatitis. Meditsinskiy sovet 2019; 2: 33–37. (In Russ.)] DOI: 10.21518/2079-701X-2019-2-33-37
5. Мурашкин Н.Н., Материкин А.И., Епишев Р.В., Амбарчян Э.Т. Особенности течения и профилактики пеленочного дерматита у новорожденных и детей грудного возраста. Вопросы современной педиатрии 2015; 14(6): 710–713. [Murashkin N.N., Materikin A.I., Epishev R.V., Ambarchyan E.T. Features of the course and prevention of diaper dermatitis in newborns and infants. Voprosy sovremennoy pediatrii 2015; 14(6): 710–713. (In Russ.)] DOI: 10.15690/vsp.v14i6.1481
6. Ebner F., Heller A., Rippke F., Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 2002; 3(6): 427–433
7. DrugBank. Dexpanthenol [Электронный ресурс]. URL: https://www.drugbank.ca/drugs/DB09357 (Дата обращения: 20.11.2020)
8. Zari S.T., Zari T.A. Wound healing, hyperpigmentant and antitumor activity of Pyrostegia venusta. Int J Res Biosci 2015; 4(4): 29–37
9. Kim К., Park J., Rhee S. Structural and functional basis for (S)-allantoin formation in in the ureide pathway. J Biol Chem 2007; 282(32): 23457-23464. DOI: 10.1074/jbc.M703211200
10. Thornfeldt C. Cosmeceuticals containing herbs: fact, fiction, and future. Dermatol Surg 2005; 31: 873–880. DOI: 10.1111/j.1524-4725.2005.31734
11. Белоусова Т.А., Каиль-Горячкина М.В. Персонифицированный подход к выбору средств базовой терапии при сухой коже. CONSILIUM MEDICUM. Дерматология 2017; 2: 38–42. [Belousova T.A., Kail-Goryachkina M.V. Personalized approach to the choice of basic therapy for dry skin. Consilium Medicum. Dermatology 2017; 2: 38–42. (In Russ.)]
12. Thioune O., Ahodikpe D., Dieng M., Diop A.B., Ngom S., Lo I. Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat). Dakar Med 2000; 45(2): 113–116
13. Листок-вкладыш Декспан плюс® Бэби https://apteka.ru/product/dekspan-plyus-bebi-krem-dlya-detej-500-5e32726465b5ab0001655e7d/. Дата доступа 11.01.2021. [Package leaflet Dexpan Plus® Baby. https://apteka.ru/product/dekspan-plyus-bebi-krem-dlya-detej-500-5e32726465b5ab0001655e7d/. Access date 11.01.2021. (In Russ.)]
14. Бокова Т.А. Памперсный (пеленочный) дерматит у новорожденного. Современные подходы к профилактике и лечению. Медицинской совет 2018; 11: 128–131. [Bokova T.A. Pampers (diaper) dermatitis in a newborn. Modern approaches to prevention and treatment. Meditsinskiy sovet 2018; 11: 128–131. (In Russ.)] DOI: 10.21518/2079-701X-2018-11-128-131
Review
For citations:
Keshishyan E.S., Sakharova E.S., Аlyamovskaya G.А., Pavlova N.V. Prevention of Diaper Irritation and Redness in Newborns and Infants: Results from the Dexpan Plus® Baby Clinical Study. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(2):130-137. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-2-130-137
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