Exudative otitis media in children: the role of prematurity and concomitant pathology in its formation. Part II
https://doi.org/10.21508/1027-4065-2021-66-5-21-27
Abstract
Despite the long-term study of exudative otitis media, the disease is not well understood. The wide prevalence of exudative otitis media in children and the increase in the incidence during recent decades explain the interest of specialists in the etiology of the disease. The article presents current views on the role of premature birth, gastroesophageal reflux, systemic and local immunodeficiency, disorders in the antioxidant defense system, mucopolysaccharidosis, genetic predisposition, and other factors in otitis media development. Unfortunately, the cause of exudative otitis media cannot always be established, and it requires further experimental and clinical studies in order to develop effective approaches to etiopathogenetically justified, timely and successful treatment of the disease and its implementation in clinical medicine.
About the Authors
I. V. Savenko
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Saint Petersburg
M. Yu. Boboshko
Pavlov First Saint Petersburg State Medical University; Mechnikov Northwest State Medical University
Russian Federation
Russian Federation
Saint Petersburg
References
1. Savenko I.V., Boboshko M.Yu. Exudative otitis media in children: the main causes. Part I. Ros Vestn Perinatol i Pediatr 2021; 66:(4): 21–38. (in Russ.) DOI: 10.21508/1027–4065–2021–66–4–32–38
2. Rakhmanova I.V., Soldatskii Yu.L., Matroskin A.G., Marenich N.S., Shelamova V.N. The role of gastroesophageal reflux disease in the development of chronic exudative otitis media. Vestnik otorinolaringologii 2018; 2: 14–16. (in Russ.) DOI: 10.17116/otorino201883214-16
3. Boronat-Echeverría N., Aguirre-Mariscal H., Carmolinga-Ponce M., Sevilla-Delgado Y., Miceli-Flores R., Kennedy-Padilla A. et al. Helicobacter pylori detection and clinical symptomatology of gastroesophageal reflux disease in pediatric patients with otitis media with effusion. Int J Pediatr Otorhinolaryngol 2016; 87: 126–129. DOI: 10.1016/j.ijporl.2016.06.023
4. Górecka-Tuteja A., JastrzÜbska I., SkáadzieĔ J., Fyderek K. Laryngopharyngeal reflux in children with chronic otitis media with effusion. J. Neurogastroenterol Motil 2016; 22(3):452–458. DOI: 10.5056/jnm16013
5. ГGarashchenko T.I., Kotov R.V., Polunin M.M. Endoscopic auditory tube surgery in children with otitis media with effusion. Rossiiskaya otorinolaringologiya. 2009; 3 (40): 34–41. (in Russ.)
6. Preobrazhenskiy N.A., Gol’dman I.I. Otitis media with effusion. M.: Medicina, 1987; 189. (in Russ.)
7. Rahmanova I.V., Zinker G.M., Matroskin A.G., Kotov R.V., Donin I.M. Middle ear pathology in premature infants of different gestational age. Vestnik Rossiiskogo gosudarstvennogo meditsinskogo universiteta 2015; 1: 21–25. (in Russ.)
8. Kemalo lu Y.K., Goksu N., Ozbilen S., Akyildiz N. Otitis media with effusion and craniofacial analysis-II: «Mastoid-middle ear-eustachian tube system» in children with secretory otitis media. Int J Pediatr Otorhinolaryngol 1995; 32(1): 69–76. DOI: 10.1016/0165-5876(94)01117-g
9. Adil E., Poe D. What is the full range of medical and surgical treatments available for patients with Eustachian tube dysfunction? Curr Opin Otolaryngol Head Neck Surg 2014; 22(1): 8–15. DOI: 10.1097/moo.0000000000000020
10. Boudewyns A., Declau F., Van der Ende J., Van Kerschaver E. Otitis media with effusion: an underestimated cause of hearing loss in infants. Otol Neurotol 2011; 32(5): 799–804. DOI: 10.1097/MAO.0b013e31821b0d07
11. Lammens F., Verhaert N., Devriendt K., Debruyne F., Desloovere C. Aetiology of congenital hearing loss: A cohort review of 569 subjects. Int J Pediatr Otorhinolaryngol 2013; 77(9): 1385–1391. DOI: 10.1016/j.ijporl.2013.06.002
12. Savenko I.V., Boboshko M.Yu. Exudative otitis media in premature infants at the first three years of life. Vrach 2014; 2: 56–59. (in Russ.)
13. Engel J., Mahler E., Anteunis L., Marres E., Zielhuis G. Why are NICU infants at risk for chronic otitis media with effusion? Int J Pediatr Otorhinolaryngol 2001; 57(2): 137–144. DOI: 10.1016/s0165-5876(00)00462-6
14. Savenko I.V., Boboshko M.Yu., Garbaruk E.S. Otitis media with effusion in children born prematurely: etiopathogenesis, course and outcomes. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae 2018; 24(4): 27–37. (in Russ.)
15. Zanchetta S., Resende L.A., Bentlin M.R., Rugulo L.M., Trindade C.E. Conductive hearing loss in children with bronchopulmonary dysplasia: a longitudinal follow-up study in children aged between 6 and 24 months. Early Hum Dev 2010; 86(6): 385–389. DOI: 10.1016/j.earlhumdev.2010.05.006
16. Coates H., Thornton R., Langlands J., Filion P., Keil A.D., Vijayasekaran S., Richmond P. The role of chronic infection in children with otitis media with effusion: evidence for intracellular persistence of bacteria. Otolaryngol Head Neck Surg 2008; 138(6): 778–781. DOI: 10.1016/j.otohns.2007.02.009
17. Ochirov D.D., Shcherbik N.V., Kologrivova E.N. The differential approach to the treatment of exudative otitis media with the use of mucosal immunocorrection. Vestnik otorinolaringologii 2012; 5: 65–68. (in Russ.)
18. Burmistrova T.V. Modern etiopathogenetic aspects of otitis media with effusion. Rossiskaya otorinolaringologiya 2004; 1(8): 25–28. (in Russ.)
19. Shcherbik N.V., Yunusov R.Sh., Starokha A.V. Pleshko R.I., Kologrivova E.N., Litvak M.M. et al. Clinical and immunological features of otitis media with effusion in children with immunocorrection. Omskii nauchnyi vestnik. Meditsinskie nauki 2014; 134(2): 66–69. (in Russ.)
20. Kim M.G., Park D.C., Shim J.S., Jung H., Park M.S., Kim Y.I. et al. TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion. Int J Pediatr Otorhinolaryngol 2010; 74(12): 1425–1429. DOI: 10.1016/j.ijporl.2010.09.026
21. Lee H.Y., Kim Y.I., Lee J.W., Byun J.Y., Park M.S., Yeo S.G. Decreased expression of TLR-9 and cytokines in the presence of bacteria in patients with otitis media with effusion. Clin Exp Otorhinolaryngol 2013; 6(4): 195–200. DOI: 10.3342/ceo.2013.6.4.195
22. Straetemans M., van Heerbeek N., Sanders E.A., Engel J.A., Schilder A.G., Rijkers G.T. et al. Immune status and Eustachian tube function in reccurence of otitis media with effusion. Arch Otolaryngol Head Neck Surg 2005; 131(9): 771–776. DOI: 10.1001/archotol.131.9.771
23. Yeo S.G., Park D.C., Lee S.K., Cha C.I. Relationship between effusion bacteria and concentration of immunoglobulin in serum and effusion fluid in otitis media with effusion patients. Int J Pediatr Otorhinolaryngol 2008; 72(3): 337–342. DOI: 10.1016/j.ijporl.2007.11.005
24. Sharma S.K., Casey J.R., Pichichero M.E. Reduced memory CD 4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition. J Infect Dis 2011; 204(4): 645–653. DOI: 10.1093/infdis/jir340
25. Smirnova M.G., Birchall J.P., Pearson J.P. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators Inflamm 2004; 13(2): 75–88. DOI: 10.1080/09629350410001688477
26. Smirnova M.G., Birchall J.P., Pearson J.P. Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion. Acta Otolaryngol 2005; 125(10): 1043–1050. DOI: 10.1080/00016480510035449
27. Skotnicka B., Hassmann E. Proinflammatory and immunoregulatory cytokines in the middle ear effusion. Int J Pediatr Otorhinolaryngol 2008; 72(1): 13–17. DOI: 10.1016/j.ijporl.2007.09.005
28. Zielnik-Jurkiewicz B., Stankiewicz-Szymczak W. Proinflammatory interleukins in middle ear effusion from atopic and non-atopic children with chronic otitis media with effusion. Eur Arch Otorhinolaryngol 2015; 273(6): 1389–1378. DOI: 10.1007/s00405-015-3683-9
29. Zielnik-Jurkiewicz B., Stankiewicz-Szymczak W. Evaluation of the interleukin-1 receptor antagonist and immunoregulatory interleukin-10 in the middle ear in chronic otitis media with effusion in children with and without atopy. Clin Exp Otorhinolaryngol 2016; 9(2): 104–108. DOI: 10.21053/ceo.2015.00129
30. Ilia S., Goulielmos G.N., Samonis G., Galanakis E. Polymorphisms in IL-6, IL-10, TNF-α, IFN-γ and TGF-β1 genes and susceptibility to acute otitis media in early infancy. Pediatr Infect Dis 2014; 33(5): 518–521. DOI: 10.1097/inf.0000000000000229
31. Ivantsova N.L., Belyakova A.G., Dmitrievskaya M.I., Mel’nikova V.M., Polevik I.V. Participation of active metabolites of vitamin D as the immunomodulator of humoral and cellular immune response. Tavricheskiy mediko-biologicheskiy vestnik 2017; 20(3): 152–158. (in Russ.)
32. Colotta F., Jansson B., Bonelli F. Modulation of inflammatory and immune responses by vitamin D. J Autoimmun 2017; 85: 78–97. DOI: 10.1016/j.jaut.2017.07.007
33. Walker R.E., Bartley J., Camargo Jr C.A., Flint D., Thompson J.M.D., Mitchell E.A. Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study. Acta Paediatr 2017; 106(9):1487–1492. DOI: 10.1111/apa.13908
34. Asghari A., Bagheri Z., Jalessi M., Salem M.M., Amini E., GhalehBaghi S. et al. Vitamin D levels in children with adenotonsillar hypertrophy and otitis media with effusion. Iran J Otorhinolaryngol 2017; 29(90): 29–33. DOI: 10.22038/ijorl.2016.8066
35. Akcan F.A., Dündar Y., Akcan H.B., Uluat A., Cebeci D., Sungur M.A., Ünlü ø. Clinical role of vitamin D in prognosis of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2018; 105: 1–5. DOI: 10.1016/j.ijporl.2017.11.030
36. Testa D., Guerra G., Marcuccio G., Landolfo P.G., Motta G. Oxidative stress in chronic otitis media with effusion. Acta Otolaryngol 2012; 132(8): 834–837. DOI: 10.3109/00016489.2012.663504
37. Sale M.M., Chen W.M., Weeks D.E., Mychaleckyj J.C., Hou X., Marion M. et al. Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). Plos One 2011; 6(8): e22297. DOI: 10.1371/journal.pone.0022297
38. Samuels T.L., Yan J.C., Khampang P., Dettmar P.W., MacKinnon A., Hong W. et al. Association of gel-forming mucins and aquaporin gene expression with hearing loss, effusion viscosity, and inflammation in otitis media with effusion. JAMA Otolaryngol. Head Neck Surg 2017; 143(8): 810–817. DOI: 10.1001/jamaoto.2017.0386
39. Mittal R., Robalino G., Gerring R., Chan B., Yan D., Grati M. et al. Immunity genes and susceptibility to otitis media: a comprehensive review. J Genet Genomics 2014; 41(11): 567–581. DOI: 10.1016/j.jgg.2014.10.003
40. Allen E.K., Chen W.-M., Weeks D.E., Chen F., Hou X., Mattos J.L. et al. A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. J. Assoc Res Otolaryngol 2013; 6(14): 791–800. DOI: 10.1007/s10162-013-0411-2
41. MacArthur C.J., Wilmot B., Wang L., Schuller M., Lighthall J., Trune D. Genetic susceptibility to chronic otitis media with effusion: candidate gene SNPs. Laryngoscope 2014; 124(5): 1229–1235. DOI: 10.1002/lary.24349
42. Einarsdottir E., Hafrén L., Leinonen E., Bhutta M.F., Kentala E., Kere J., Mattila P.S. Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion. Sci Rep 2016; 6: 33240. DOI: 10.1038/srep33240
43. Andersen T.N., Alanin M.C., von Buchwald C., Nielsen L.H. A longitudinal evaluation of hearing and ventilation tube insertion in patients with primary ciliary dyskinesia. Int J Pediatr Otorhinolaryngol 2016; 89: 164–168. DOI: 10.1016/j.ijporl.2016.08.011
44. Zanetti D., Vezzani M., Di Bernandino F., Gasperini S., Parini R. Characterization of hearing loss in children with mucopolysaccharidosis. In.: An excursus into hearing loss. Ed.: S. Hatzopoulos, A. Ciorba. London: IntechOpen Limited, 2018: 55–70. DOI: 10.5772/intechopen.74196
45. Chantzi F.M., Papadopoulos N.G., Bairamis T., Tsiakou M., Bournousouzis N., Constantopoulos A.G. Human rhinoviruses in otitis media with effusion. Pediatr. Allergy Immunol 2006; 17(7): 514–518. DOI: 10.1111/j.1399-3038.2006.00448.x
46. Kaya S., Selimo÷lu E., Cureo÷lu S., Selimo÷lu M.A. Relationship between chronic otitis media with effusion and overweight or obesity in children. J Laryngol Otol 2017; 131(10): 866–870. DOI: 10.1017/S002221511700161X
47. Walker R.E., Bartley J., Flint D., Thompson J.M., Mitchell E.A. Determinants of chronic otitis media with effusion in preschool children: a case-control study. BMC Pediatrics 2017; 17(1):4. DOI: 10.1186/s12887-016-0767-7
48. Dmitriev N.S., Mileshina N.A., Kolesova L.I. Otitis media with effusion in children: guidelines. M.: Nauchnyy tsentr audiologii i slukhoprotezirovaniya, 1996. 22. (in Russ.)
49. Kong S.K., Chon K.M., Goh E.K., Lee I.W., Lee J.W., Wang S.G. Histologic changes in the auditory tube mucosa of rats after long-term exposure to cigarette smoke. Am J Otolaryngol 2009; 30(6): 376–382. DOI: 10.1016/j.amjoto.2008.07.009
50. Mills R., Hathorn I. Aetiology and pathology of otitis media with effusion in adult life. J Laryngol Otol 2016; 130(5): 418–424. DOI: 10.1017/S0022215116000943
51. Savenko I.V., Boboshko M. Yu. Otitis media with effusion. SPb.: Dialog, 2020; 168. (in Russ.)
Review
For citations:
Savenko I.V., Boboshko M.Yu. Exudative otitis media in children: the role of prematurity and concomitant pathology in its formation. Part II. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(5):21-27. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-5-21-27
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