Clinical manifestations and differential diagnosis of atopic dermatitis in young children
https://doi.org/10.21508/1027-4065-2021-66-5-141-149
Abstract
Atopic dermatitis is one of the most common dermatological diseases in infants and young children. The disease is characterized by a chronic recurrent course with itching, erythema, lichenification and desquamation. Typical cases are diagnosed on the clinically available diagnostic criteria. However, similar clinical manifestations are found in a number of other diseases that can simulate, accompany or complicate the course of atopic dermatitis. They include inflammatory skin conditions, infections, parasitic diseases, genodermatoses, immunodeficiencies and malignancies, as well as nutritional disorders, graft-versus-host disease, and drug disease. Knowledge of the spectrum of these diseases and their distinctive features is crucial for the correct and timely diagnosis of atopic dermatitis, the selection of the optimal treatment.
About the Authors
A. S. Botkinа
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
M. I. Dubrovskaya
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
A. B. Moiseev
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
E. E. Vartapetova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
References
1. Pawankar R., Canonica G.W., Holgate S.T., Richard F.L. On behalf of the World Allergy Organization (WAO), the authors of the WAO White Book on Allergy 2011–2012: Executive Summary express their gratitude to the charity, Asthma, Allergy, and Inflammation Research (AAIR) for support in the production of this publication. United States of America, 2012; 220
2. Nevozinskaya Z.A., Plieva K.T., Korsunskaya I.M. Possibilities of controlling the course of atopic dermatitis. Consilium Medicum. Dermatologiya 2016; 1: 49–54. (in Russ.)
3. Barbarot S., Auziere S., Gadkari A., Girolomoni G., Puig L., Simpson E. L. et al. Epidemiology of atopic dermatitis in adults: results from an international survey. Allergy 2018; 73: 1284–1293. DOI: 10.1111/all.13401
4. Korotkiy N.G., Tikhomirov A.A., Taganov A.V., Moiseenko A.V. Atopic dermatitis in children. A guide for doctors. Tver: Triada, 2003; 238. (in Russ.)
5. European guidelines for the treatment of dermatological diseases. Ed. by A.D. Katsambas, T.M. Lotti. M.: MEDpress-inform, 2009; 724. (in Russ.)
6. Czarnowicki T., Krueger J.G., Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol 2017;139: 1723–1734. DOI: 10.1016/j.jaci.2017.04.004
7. Tran M.M., Lefebvre D.L., Dharma C., Dai D., Lou W.Y.W., Subbarao P. et al. Canadian Healthy Infant Longitudinal Development Study investigators. Predicting the atopic march: results from the Canadian Healthy Infant Longitudinal Development Study. J Allergy Clin Immunol 2018; 141:601–607. DOI: 10.1016/j.jaci.2017.08.024
8. Bieber T., D’Erme A.M., Akdis C.A., Traidl-Hoffmann С., Lauener R., Schäppi G., Schmid-Grendelmeier P. Clinical phenotypes and endophenotypes of atopic dermatitis: where are we, and where should we go? J Allergy Clin Immunol 2017; 139: S58–S64. DOI: 10.1016/j.jaci.2017.01.008
9. Chello C., Carnicelli G., Sernicola A., Gagliostro N., Paolino G., Fraia M.D. et al. Atopic dermatitis in the elderly Caucasian population: diagnostic clinical criteria and review of the literature. Int J Dermatol 2020; 59: 716–721. DOI: 10.1111/ijd.14891
10. Song H.S., Jung S-E., Kim Y.C., Lee E.-S. Nipple eczema, an indicative manifestation of atopic dermatitis? A clinical, histological, and immunohistochemical study. Am J Dermatopathol 2015; 37: 284–288. DOI: 10.1097/DAD.0000000000000195
11. Kellen R., Silverberg N.B. Pediatric periorificial dermatitis. Cutis 2017; 100: 385–388
12. Yew Y.W., Thyssen J.P., Silverberg J.I. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol 2019; 80:390–401. DOI: 10.1016/j.jaad.2018.09.035
13. Govind K., Whang K., Khanna R., Scott A.W., Kwatra S.G. Atopic dermatitis is associated with increased prevalence of multiple ocular comorbidities. J Allergy Clin Immunol Pract 2019; 7: 298–299. DOI: 10.1016/j.jaip.2018.10.009
14. Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980; 92: 44–47
15. Eichenfield L.F., Hanifin J.M., Luger T.A., Stevens S.R., Pride H.B. Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol 2003; 49: 1088–1095. DOI: 10.1016/s0190-9622(03)02539-8
16. Alexopoulos A., Kakourou T., Orfanou I., Xaidara A., Chrousos G. Retrospective analysis of the relationship between infantile seborrheic dermatitis and atopic dermatitis. Pediatr Dermatol 2014; 31: 125–130. DOI: 10.1111/pde.12216
17. Krol A., Krafchik B. The differential diagnosis of atopic dermatitis in childhood. Dermatol Ther 2006; 19: 73–82. DOI: 10.1111/j.1529-8019.2006.00058.x
18. Traupe H., Fischer J., Oji V. Nonsyndromic types of ichthyoses – An update. J Dtsch Dermatol Ges 2014; 12: 109–121. DOI: 10.1111/ddg.12229
19. Bremmer S.F., Hanifin J.M., Simpson E.L. Clinical detection of ichthyosis vulgaris in an atopic dermatitis clinic: Implications for allergic respiratory disease and prognosis. J Am Acad Dermatol 2008; 59: 72–78. DOI: 10.1016/j.jaad.2008.03.029
20. Suebsarakam P., Chaiyarit J., Techasatian L. Diaper Dermatitis: Prevalence and Associated Factors in 2 University Daycare Centers. J Prim Care Community Health 2020; 11:2150132719898924. DOI: 10.1177/2150132719898924
21. Orrico J.A., Krause-Parello C.A. Facts, fiction, and figures of the Sarcoptes scabiei infection. J Sch Nurs 2010; 26: 260–266. DOI: org/10.1177/1059840510375413
22. Lebsing S., Chaiyarit J., Techasatian L. Diaper rashes can indicate systemic conditions other than diaper dermatitis. BMC Dermatol 2020; 20: 7. DOI: 10.1186/s12895-020-00104-z
23. Ricci G., Ferrari S., Calamelli E., Ricci L., Neri I., Patrizi A. Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature. Int J Immunopathol Pharmacol 2016; 29(2): 274–279. DOI: 10.1177/0394632015606845
24. Jezierska M., Stefanowicz J., Romanowicz G., Kosiak W., Lange M. Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Postepy Dermatol Alergol 2018; 35(1): 6–17. DOI: 10.5114/pdia.2017.67095
25. Pope E., Weitzman S., Ngan B., Walsh S., Morel K., Williams J. et al. Mycosis fungoides in the pediatric population: Report from an international Childhood Registry of Cutaneous Lymphoma. J Cutan Med Surg 2010; 14: 1–6. DOI: 10.2310/7750.2009.08091
26. Weisshaar E., Weiss M., Mettang T., Yosipovitch G., Zylicz Z. Special Interest Group of the International Forum on the Study of Itch. Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI). Acta Derm Venereol 2015; 95: 261–265. DOI: 10.2340/00015555-1959
Review
For citations:
Botkinа A.S., Dubrovskaya M.I., Moiseev A.B., Vartapetova E.E. Clinical manifestations and differential diagnosis of atopic dermatitis in young children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(5):141-149. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-5-141-149
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