Primary schlerosing cholangitis in children with inflammatory bowel disease
https://doi.org/10.21508/1027-4065-2021-66-5-150-156
Abstract
The article provides an overview of current data on clinical features, modern diagnostic methods and therapeutic strategies for primary sclerosing cholangitis in children with inflammatory bowel disease. Primary sclerosing cholangitis can be asymptomatic for a long time, acquiring a progressive character with liver cirrhosis. The disease is one of the most important risk factors for the development of cholangiocarcinoma. The article presents a diagnostic algorithm for increased transaminases in the serum of the children with inflammatory bowel disease, with an emphasis on various variants of hepatobiliary pathology including primary sclerosing cholangitis. The widespread application of the pediatric scale SCOPE (Sclerosing Cholangitis Outcomes in Pediatrics index) will allow us to timely diagnose and prescribe treatment for a patient with primary sclerosing cholangitis at an early stage improving the prognosis of the disease.
About the Authors
A. A. Kamalova
Kazan State Medical University; Children’s Republican Clinical Hospital of Tatarstan Republic
Russian Federation
Russian Federation
Kazan
A. R. Gaifutdinova
Kazan State Medical University; Children’s Republican Clinical Hospital of Tatarstan Republic
Russian Federation
Russian Federation
Kazan
A. A. Malov
Kazan State Medical University; Children’s Republican Clinical Hospital of Tatarstan Republic
Russian Federation
Russian Federation
Kazan
E. R. Safina
Kazan State Medical University
Russian Federation
Russian Federation
Kazan
R. A. Nizamova
Children’s Republican Clinical Hospital of Tatarstan Republic
Russian Federation
Russian Federation
Kazan
L. I. Basanova
Children’s Republican Clinical Hospital of Tatarstan Republic
Russian Federation
Russian Federation
Kazan
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Review
For citations:
Kamalova A.A., Gaifutdinova A.R., Malov A.A., Safina E.R., Nizamova R.A., Basanova L.I. Primary schlerosing cholangitis in children with inflammatory bowel disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(5):150-156. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-5-150-156
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