Immune-mediated epilepsies in children
Abstract
The paper reviews the current literature on immune-mediated pediatric epilepsies. It describes the clinical picture, laboratory diagnosis, and treatment of autoimmune encephalitides (limbic encephalitis and anti-NMDA-receptor antibody encephalitis), Hashimoto's encephalopathy, opsoclonus-myoclonus-syndrome, and Rasmussen's syndrome, as well as groups of acute encephalopathies with immune-mediated status epilepticus (FIRES-, DESK-, HHE- syndrome). A clinical case of Hashimoto's encephalopathy is described. Emphasis is laid on a close relationship between epilepsy and inflammation, including the development of an autoimmune process due to recurrent epileptic seizures.
About the Authors
E. D. Belousova
Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow
Russian Federation
Russian Federation
M. I. Yablonskaya
Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow
Russian Federation
Russian Federation
M. K. Tagirova
Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow
Russian Federation
Russian Federation
S. L. Kulikova
Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus
Russian Federation
Russian Federation
S. A. Likhachev
Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus
Russian Federation
Russian Federation
References
1. Vezzani A., French J., Bartfai Т., Baram T.Z. The role of inflammation in epilepsy. Nat Rev Neurol 2011; 7: 1: 31 —40.
2. RiaziK., Galic M.A., Pittman Q.J. Contributions of peripheral inflammation to seizure susceptibilityxytokines and brain excitability. Epilepsy Res 2010; 89: 34-42.
3. Ravizza Т., Balosso S., Aronica E., Vezzani A. Epilepsy: Mechanisms, Models, and Translational Perpsectives. J.M. Rho (ed). Boca Raton: CRC Press 2010; 45-59.
4. Armangue Т., Petit-PedrolM., Dalmau J. Autoimmune Encephalitis in Children. J Child Neurol 2012; 27:11:1460-1469.
5. Dalmau J. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011; 10: 1:63-74.
6. Bien C.G., Vincent A. Immune-mediated pediatric epilepsies. In Handbook of Clinical Neurology, Vol. Ill (3rd series) Pediatric Neurology Part I. O. Dulac, M. Lassonde, H.B. Sarnat (eds). ElsevierB.V., 2013; 565.
7. Haberlandt E., Bast Т., Ebner A. et al. Limbic encephalitis in children and adolescents. Arch Dis Child 2011; 96: 186-191.
8. Darnell R.B., PosnerJ.B. A new cause of limbic encephalopa-thy. Brain 2005; 128: 1745-1746.
9. Yu E.G., Lee J., Seo D. W., Lee M. Clinical Manifestations and Treatment Response of Steroid in Pediatric Hashimoto En-cephalopathy. J Child Neurol 2014; 29: 938-942.
10. Gul Mert G., Horoz O.O., Herguner M.O. et al. Hashimoto's encephalopathy: four cases and review of literature. Inter J Neurosci 2014; 124: 4: 302-306.
11. OlmezL., Moses H., Sriram S. etal. Diagnostic and therapeutic aspects of Hashimoto's encephalopathy. J Neurol Sci 2013; 331:67-71.
12. Varadkar S., Bien C.G., Kruse C.A. et al. Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances. Lancet Neurol 2014; 13: 195-205.
13. Ramaswamy V, Walsh J.G., SinclairD.B. etal. Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis. J Neuroinflammation 2013; 13: 10:152.
14. Wang D., Blumcke L., Gui Q. et al. Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia. Epileptic Disord2013; 15:1:32-43.
15. Dawodu CO., Akinbo D.D. Rasmussen's encephalitis. Niger J ClinPract2013; 16: 1: 113-115.
16. Pike M. Opsoclonus-myoclonus syndrome. In Handbook of Clinical Neurology, Vol. 112 (3rd series) Pediatric Neurology Part II O. Dulac, M. Lassonde, H.B. Sarnat (eds). Elsevier B.V, 2013; 1209-1211.
17. Байдун Л.В., Семыкина Л.И., Петрухин А.С. и др. Опсо-клонус-миоклонус-синдром у детей. Журн неврол и пси-хиат 2007; 2: 4-11. (Baidun L.V, Semikina L.I., Petruchin A.S. et al. Opsoclonus-myoclonus syndrome u detei. Zhurn Nevrol i Psikhiatr 2007; 2:4-11.)
18. SahuJ.K., Prasad K. Opsoclonus-myoclonus syndrome. Pract Neurol 2011; 11: 160-166.
19. Cross J.H. Fever and fever-related epilepsies. Epilepsia 2012; 53: Suppl 4: 3-8.
20. Сивкова М.Н., Богданов Э.И., Зайкова Ф.М. и др. Феб-рильно-обусловленная рефрактерная эпилептическая энцефалопатия у детей. Журн неврол и психиат 2013; 113: 6: 11—16. (Sivkova S.N., Bogdanov E.I., ZakovaF.M. et al. Fever-induced refractory epileptic encephalopathy of children. Zhurn Nevrol iPsikhiat 2013; 113: 6: 11-16.)
21. Auvin S., Bellavoine V, Merdariu D. et al. Hemiconvulsion-hemiplegia-epilepsy syndrome: Current understandings. Eur J Pediat Neurol 2012; 16: 5: 413-421.
22. Tenney J.R., Schapiro M.B. Child Neurology: Hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology 2012; 79: el—e4.
Review
For citations:
Belousova E.D., Yablonskaya M.I., Tagirova M.K., Kulikova S.L., Likhachev S.A. Immune-mediated epilepsies in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(5):26-32. (In Russ.)
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