Kawasaki syndrome: Risk factors for coronary artery aneurysms
Abstract
Kawasaki syndrome is a childhood systemic vasculitis that may affect coronary arteries, further leading to myocardial ischemia or myocardi-al infarction. This investigation is our country's first experience with regression analysis to find risk factors for coronary artery involvement in Kawasaki syndrome. The outpatient and inpatient medical records of 168 KD patients aged 1 month 13 days to 13 years 6 months were retrospectively analyzed. Results. The investigators revealed risk factors for coronary artery involvement: persistent fever; prolonged fever prior to immunoglobulin infusion; low hemoglobin in acute phase; leukocytosis more than 17* 109/l in acute phase; thrombocytosis more than 790-109/! and obviously increased erythrocyte sedimentation rate; a more than 5-fold rise in normal C-reactive protein; immunoglobulin administration after day 10; and no immunoglobulin therapy. The dose of immunoglobulin of 2 g/kg reduces the risk of coronary artery aneurysms, but its effect depends on the day of administration. Cervical lymphadenopathy and immunoglobulin resistance may be risk factors for coronary artery aneurysms, but further investigations are needed to solve this problem.
About the Authors
A. V. Torbyak
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
O. G. Shirinskaya
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
G. A. Lyskina
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
A. A. Leontyeva
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
E. V. Prutskova
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
E. B. Melkumyan
I.M. Sechenov First Moscow State Medical University, Moscow; Higher School of Economics, National Research University; Saint Tikhon's Orthodox University of Humanities, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Torbyak A.V., Shirinskaya O.G., Lyskina G.A., Leontyeva A.A., Prutskova E.V., Melkumyan E.B. Kawasaki syndrome: Risk factors for coronary artery aneurysms. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(5):79-84. (In Russ.)
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