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Поражение желудочно-кишечного тракта у детей с COVID-19: от патогенеза до клинических проявлений
https://doi.org/10.21508/1027-4065-2022-67-5-123-129
Аннотация
С начала пандемии новая коронавирусная инфекция расценивалась преимущественно как респираторное заболевание. К настоящему времени стало очевидным, что COVID-19 — системный инфекционный процесс с полиорганным поражением. Имея тропность к рецепторам ангиотензинпревращающего фермента 2-го типа, вирус способен поражать клетки как респираторного тракта, так и сердечно-сосудистой, и нервной систем, гладкомышечные структуры разных органов. Экспрессия ангиотензинпревращающего фермента 2-го типа энтероцитами тонкой кишки делает уязвимым желудочно-кишечный тракт при заболевании COVID-19 и приводит к манифестации симптомов его поражения, что нередко наблюдается в клинической практике. Симптоматика поражения желудочно-кишечного тракта обычно включает анорексию, тошноту, рвоту, диарею и боль в животе, которые могут проявляться как в дебюте, так и в ходе развития самого заболевания. Описывается несколько механизмов, объясняющих такого рода изменения при COVID-19.
При поддержке: Работа выполнена при финансовой поддержке ФГБОУ ВО Казанский ГМУ Минздрава России (Грант № 2/22–1 от 1.08.2022 года).
Об авторах
В. А. Поздняк
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Россия
аспирант кафедры детских инфекций,
420012 Казань, ул. Бутлерова, д. 49
С. В. Халиуллина
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Россия
д.м.н., доц. кафедры детских инфекций,
420012 Казань, ул. Бутлерова, д. 49
В. А. Анохин
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Россия
д.м.н., проф., зав. кафедрой детских инфекций,
420012 Казань, ул. Бутлерова, д. 49
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Рецензия
Для цитирования:
Поздняк В.А., Халиуллина С.В., Анохин В.А. Поражение желудочно-кишечного тракта у детей с COVID-19: от патогенеза до клинических проявлений. Российский вестник перинатологии и педиатрии. 2022;67(5):123-129. https://doi.org/10.21508/1027-4065-2022-67-5-123-129
For citation:
Pozdnyak V.A., Khaliullina S.V., Anokhin V.A. Gastrointestinal tract lesion in children with COVID-19: from pathogenesis to clinical manifestations. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2022;67(5):123-129. (In Russ.) https://doi.org/10.21508/1027-4065-2022-67-5-123-129
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