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Assessment of the arginine and glutamic acid content in the blood serum of full-term newborns with intrauterine growth retardation
I. V. Kravchenko,
I. I. Krukier,
A. A. Afonin,
M. A. Levkovich,
S. B. Berezhanskaya,
O. V. Avilova,
O. Z. Puzikova,
D. I. Sozaeva https://doi.org/10.21508/1027-4065-2023-68-1-16-23
Abstract
The problem of intrauterine growth retardation is currently relevant, as it is one of the causes of neonatal morbidity and mortality. Purpose. To study the course of the neonatal period and evaluate the content of arginine and glutamic acid in full-term newborns depending on the severity of intrauterine growth retardation.
Material and methods. 78 full-term newborns with intrauterine growth retardation according to hypotrophic type were examined. The content of glutamic acid and arginine in blood serum was determined in the early neonatal period by capillary electrophoresis using an unmodified quartz capillary (Kapel-105, Lumeks, St. Petersburg, Russia).
Results. Markers of the formation of a severe degree of intrauterine growth retardation were identified: increased levels of glutamic acid and arginine, taking into account impaired cerebral blood flow in the early neonatal period. A model is proposed for predicting the persistence of a severe degree of intrauterine growth retardation in newborns by the end of the neonatal period.
Conclusion. The proposed diagnostic criteria make it possible to start specific therapy in a timely manner in order to prevent the formation of a severe degree of intrauterine growth retardation.
About the Authors
I. V. Kravchenko
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
I. I. Krukier
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
A. A. Afonin
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
M. A. Levkovich
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
S. B. Berezhanskaya
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
O. V. Avilova
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
O. Z. Puzikova
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
D. I. Sozaeva
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
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Review
For citations:
Kravchenko I.V., Krukier I.I., Afonin A.A., Levkovich M.A., Berezhanskaya S.B., Avilova O.V., Puzikova O.Z., Sozaeva D.I. Assessment of the arginine and glutamic acid content in the blood serum of full-term newborns with intrauterine growth retardation. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2023;68(1):16-23. (In Russ.) https://doi.org/10.21508/1027-4065-2023-68-1-16-23
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