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Diagnostic significance of the extracellular matrix structures in bronchial asthma in children
https://doi.org/10.21508/1027-4065-2023-68-3-41-45
Abstract
The intercellular matrix in bronchial asthma is involved in both reversible and irreversible processes of structural change. Markers of endothelial disorders, indicators of extracellular matrix structures may have diagnostic significance.
Purpose. To study the clinical significance of markers of collagen genesis and plasma endothelin-1 in bronchial asthma in children, depending on the severity and duration of the disease.
Material and methods. 268 patients aged from 2 years 11 months to 17 years 11 months with an established diagnosis of bronchial asthma with varying degrees of severity were examined. The ELISA method determined the serum levels of the following indicators: antibodies to type I and type III collagen, plasma endothelin.
Results. There was a significantly significant increase in fibroblast growth factor, type I collagen antibodies in children with severe bronchial asthma.
Conclusion. These indicators are a diagnostic marker for a severe bronchial asthma.
About the Authors
T. R. Stroykova
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
O. A. Bashkina
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
N. A. Geppe
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Stroykova T.R., Bashkina O.A., Geppe N.A. Diagnostic significance of the extracellular matrix structures in bronchial asthma in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2023;68(3):41-45. (In Russ.) https://doi.org/10.21508/1027-4065-2023-68-3-41-45
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