Role of genetics in the development of pediatric nephrology
Abstract
Generalized data on the role of medical genetics in the development of pediatric nephrology are given on the basis of the authors’ observations and modern literature. It is shown that the introduction of genetic researches into the practice of a pediatric nephrologist can change the view of the etiology of many diseases, decipher the essence of a number of nephropathies, the cause of which was unclear, and reduce the number of idiopathic diseases. This is particularly important for the determination of therapeutic tactics and the emergence of new pathogenic agents that can improve prognosis and quality of life in patients in a number of genetic diseases. Particular attention is drawn to hereditary nephropathy accompanied by hematuria and particularly to Alport syndrome characterized by a progressive course. The development of genetics and clinical introduction of its advances have recently led to the identification of a new nosological entity — hereditary C3 glomerulonephritis as a result of CFHR5 gene mutation. Thanks to the development of genetic technologies, new genetic kidney diseases are certain to be disclosed in the next future.
About the Authors
M. S. Ignatova
Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health Russia, of Moscow
Russian Federation
Russian Federation
V. V. Dlin
Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health Russia, of Moscow
Russian Federation
Russian Federation
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Review
For citations:
Ignatova M.S., Dlin V.V. Role of genetics in the development of pediatric nephrology. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(3):6-9. (In Russ.)
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