Mechanisms for development of anemia and its severity in children with chronic kidney disease
Abstract
The literature review summarizes current information on the causes of and mechanisms for the development of anemia in children with chronic kidney disease. It demonstrates the relationship between the severity of anemia and iron metabolism, hepcidin, erythropoietin deficiency, and changes in the levels of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in different stages of chronic kidney disease in children. There are data on the value of HIF-1α in stimulating erythropoiesis in the early stages of chronic kidney disease. The studies have shown a reduction in HIF-1α in the later stages of this disease.
About the Authors
E. V. Lysova
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
N. D. Savenkova
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
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Review
For citations:
Lysova E.V., Savenkova N.D. Mechanisms for development of anemia and its severity in children with chronic kidney disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(3):31-36. (In Russ.)
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